Impact of asthma on COVID-19 mortality in the United States: Evidence based on a meta-analysis.
Int Immunopharmacol
; 102: 108390, 2022 Jan.
Article
in English
| MEDLINE | ID: covidwho-1525826
ABSTRACT
OBJECTIVE:
The aim of this study was to investigate the impact of asthma on the risk for mortality among coronavirus disease 2019 (COVID-19) patients in the United States by a quantitative meta-analysis.METHODS:
A random-effects model was used to estimate the pooled odds ratio (OR) with corresponding 95% confidence interval (CI). I2 statistic, sensitivity analysis, Begg's test, meta-regression and subgroup analyses were also performed.RESULTS:
The data based on 56 studies with 426,261 COVID-19 patients showed that there was a statistically significant association between pre-existing asthma and the reduced risk for COVID-19 mortality in the United States (OR 0.82, 95% CI 0.74-0.91). Subgroup analyses by age, male proportion, sample size, study design and setting demonstrated that pre-existing asthma was associated with a significantly reduced risk for COVID-19 mortality among studies with age ≥ 60 years old (OR 0.79, 95% CI 0.72-0.87), male proportion ≥ 55% (OR 0.79, 95% CI 0.72-0.87), male proportion ï¼ 55% (OR 0.81, 95% CI 0.69-0.95), sample sizes ≥ 700 cases (OR 0.80, 95% CI 0.71-0.91), retrospective study/case series (OR 0.82, 95% CI 0.75-0.89), prospective study (OR 0.83, 95% CI 0.70-0.98) and hospitalized patients (OR 0.82, 95% CI 0.74-0.91). Meta-regression did reveal none of factors mentioned above were possible reasons of heterogeneity. Sensitivity analysis indicated the robustness of our findings. No publication bias was detected in Begg's test (P = 0.4538).CONCLUSION:
Our findings demonstrated pre-existing asthma was significantly associated with a reduced risk for COVID-19 mortality in the United States.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Asthma
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
Limits:
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Int Immunopharmacol
Journal subject:
Allergy and Immunology
/
Pharmacology
Year:
2022
Document Type:
Article
Affiliation country:
J.intimp.2021.108390
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