Advanced applications of mass spectrometry imaging technology in quality control and safety assessments of traditional Chinese medicines.
J Ethnopharmacol
; 284: 114760, 2022 Feb 10.
Article
in English
| MEDLINE | ID: covidwho-1525847
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE Traditional Chinese medicines (TCMs) have made great contributions to the prevention and treatment of human diseases in China, and especially in cases of COVID-19. However, due to quality problems, the lack of standards, and the diversity of dosage forms, adverse reactions to TCMs often occur. Moreover, the composition of TCMs makes them extremely challenging to extract and isolate, complicating studies of toxicity mechanisms. AIM OF THE REVIEW The aim of this paper is therefore to summarize the advanced applications of mass spectrometry imaging (MSI) technology in the quality control, safety evaluations, and determination of toxicity mechanisms of TCMs. MATERIALS AND METHODS:
Relevant studies from the literature have been collected from scientific databases, such as "PubMed", "Scifinder", "Elsevier", "Google Scholar" using the keywords "MSI", "traditional Chinese medicines", "quality control", "metabolomics", and "mechanism".RESULTS:
MSI is a new analytical imaging technology that can detect and image the metabolic changes of multiple components of TCMs in plants and animals in a high throughput manner. Compared to other chemical analysis methods, such as liquid chromatography-mass spectrometry (LC-MS), this method does not require the complex extraction and separation of TCMs, and is fast, has high sensitivity, is label-free, and can be performed in high-throughput. Combined with chemometrics methods, MSI can be quickly and easily used for quality screening of TCMs. In addition, this technology can be used to further focus on potential biomarkers and explore the therapeutic/toxic mechanisms of TCMs.CONCLUSIONS:
As a new type of analysis method, MSI has unique advantages to metabolic analysis, quality control, and mechanisms of action explorations of TCMs, and contributes to the establishment of quality standards to explore the safety and toxicology of TCMs.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Mass Spectrometry
/
Drugs, Chinese Herbal
/
SARS-CoV-2
/
COVID-19 Drug Treatment
/
Medicine, Chinese Traditional
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Reviews
Topics:
Traditional medicine
Limits:
Humans
Language:
English
Journal:
J Ethnopharmacol
Year:
2022
Document Type:
Article
Affiliation country:
J.jep.2021.114760
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