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Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD.
Dinoto, Alessandro; Sechi, Elia; Ferrari, Sergio; Gajofatto, Alberto; Orlandi, Riccardo; Solla, Paolo; Maccabeo, Alessandra; Maniscalco, Giorgia Teresa; Andreone, Vincenzo; Sartori, Arianna; Manganotti, Paolo; Rasia, Sarah; Capra, Ruggero; Mancinelli, Chiara Rosa; Mariotto, Sara.
  • Dinoto A; Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Italy.
  • Sechi E; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
  • Ferrari S; Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Italy.
  • Gajofatto A; Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Italy.
  • Orlandi R; Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Italy.
  • Solla P; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy.
  • Maccabeo A; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Italy; Department of Medical Sciences and Public Health, University of Cagliari, Italy.
  • Maniscalco GT; Department of Neurology and Stroke Unit "A. Cardarelli Hospital", Naples, Italy.
  • Andreone V; Department of Neurology and Stroke Unit "A. Cardarelli Hospital", Naples, Italy.
  • Sartori A; Neurology Unit, Department of Medical, Surgical and Health Sciences, Cattinara University Hospital, ASUGI, University of Trieste, Trieste, Italy.
  • Manganotti P; Neurology Unit, Department of Medical, Surgical and Health Sciences, Cattinara University Hospital, ASUGI, University of Trieste, Trieste, Italy.
  • Rasia S; Multiple Sclerosis Center, ASST - Spedali Civili of Brescia, Montichiari, Brescia, Italy.
  • Capra R; Multiple Sclerosis Center, ASST - Spedali Civili of Brescia, Montichiari, Brescia, Italy.
  • Mancinelli CR; Multiple Sclerosis Center, ASST - Spedali Civili of Brescia, Montichiari, Brescia, Italy.
  • Mariotto S; Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Italy. Electronic address: sara.mariotto@gmail.com.
Mult Scler Relat Disord ; 58: 103424, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1525909
ABSTRACT
Post-vaccination disease relapses have been reported in patients with MOGAD and AQP4-IgG+NMOSD. In this retrospective multicenter Italian study we assessed the frequency of relapses after SARS-CoV-2 vaccination. We included 56 cases MOGAD, 30; AQP4-IgG+NMOSD, 26. Vaccines received were BNT162b2-Pfizer-BioNTech in 42 patients and mRNA-1273-Moderna in 14 patients. Six patients had a history of SARS-CoV-2 infection; two of them experienced a post-infection disease relapse (MOGAD). The frequency of relapses within one month of SARS-CoV-2 vaccination was 4% (1/26) in the AQP4-IgG+NMOSD group and 0% in the MOGAD group. In these patients the potential benefits of vaccination overcome the risk of relapses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article Affiliation country: J.msard.2021.103424

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article Affiliation country: J.msard.2021.103424