Histone mimics: more tales to read.
Biochem J
; 478(14): 2789-2791, 2021 07 30.
Article
in English
| MEDLINE | ID: covidwho-1526112
ABSTRACT
Post-translational modifications (PTMs) on histone proteins are known as epigenetic marks that demarcate the status of chromatin. These modifications are 'read' by specific reader proteins, which in turn recruit additional factors to modulate chromatin accessibility and the activity of the underlying DNA. Accumulating evidence suggests that these modifications are not restricted solely to histones, many non-histone proteins may function in a similar way through mimicking the histones. In this commentary, we briefly discuss a systematic study of the discovery of histone H3 N-terminal mimicry proteins (H3TMs), and their implications in chromatin regulation and drug discoveries.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
DNA
/
Chromatin
/
Histones
/
Protein Processing, Post-Translational
Type of study:
Systematic review/Meta Analysis
Limits:
Animals
/
Humans
Language:
English
Journal:
Biochem J
Year:
2021
Document Type:
Article
Affiliation country:
BCJ20210357
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