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Progress in aorta and peripheral cardiovascular disease research.
Mazzolai, Lucia; Alatri, Adriano; Rivière, Alessandra Bura; De Carlo, Marco; Heiss, Christian; Espinola-Klein, Christine; Schlager, Oliver; Sillesen, Henrik; Staub, Daniel; Rodriguez-Palomares, José F; Verstraeten, Aline; Aboyans, Victor.
  • Mazzolai L; Division of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Alatri A; Division of Angiology, Heart and Vessel Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Rivière AB; Division of Vascular Medicine, Heart, Vessels and Metabolisms Department, Toulouse University Hospital, Toulouse, France.
  • De Carlo M; Cardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
  • Heiss C; Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
  • Espinola-Klein C; Section Angiology, Department of Cardiology, Cardiology I, University Medical Center Mainz, Mainz, Germany.
  • Schlager O; Division of Angiology, Department of Medicine II, Medical University of Vienna, Waehringer Gürtel 18-20, 1090 Vienna, Austria.
  • Sillesen H; Department of Vascular Surgery, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Staub D; Division of Angiology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Rodriguez-Palomares JF; Cardiology Department, Hospital General Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), CIBER-CV, Barcelona, Spain.
  • Verstraeten A; Centre of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.
  • Aboyans V; Department of Cardiology, Dupuytren-2 University Hospital, and Inserm 1094 & IRD, Limoges University, Limoges, France.
Cardiovasc Res ; 117(9): 2045-2053, 2021 07 27.
Article in English | MEDLINE | ID: covidwho-1526155
Semantic information from SemMedBD (by NLM)
1. Laboratory Procedures USES MAL gene|CD8A|MAL|MKL1|TIRAP
Subject
Laboratory Procedures
Predicate
USES
Object
MAL gene|CD8A|MAL|MKL1|TIRAP
2. Magnetic Resonance Imaging CAUSES Cerebrovascular accident
Subject
Magnetic Resonance Imaging
Predicate
CAUSES
Object
Cerebrovascular accident
3. Lower Extremity LOCATION_OF Peripheral Arterial Diseases
Subject
Lower Extremity
Predicate
LOCATION_OF
Object
Peripheral Arterial Diseases
4. Laboratory Procedures USES MAL gene|CD8A|MAL|MKL1|TIRAP
Subject
Laboratory Procedures
Predicate
USES
Object
MAL gene|CD8A|MAL|MKL1|TIRAP
5. Magnetic Resonance Imaging CAUSES Cerebrovascular accident
Subject
Magnetic Resonance Imaging
Predicate
CAUSES
Object
Cerebrovascular accident
6. Lower Extremity LOCATION_OF Peripheral Arterial Diseases
Subject
Lower Extremity
Predicate
LOCATION_OF
Object
Peripheral Arterial Diseases
ABSTRACT
Although coronavirus disease 2019 seems to be the leading topic in research number of outstanding studies have been published in the field of aorta and peripheral vascular diseases likely affecting our clinical practice in the near future. This review article highlights key research on vascular diseases published in 2020. Some studies have shed light in the pathophysiology of aortic aneurysm and dissection suggesting a potential role for kinase inhibitors as new therapeutic options. A first proteogenomic study on fibromuscular dysplasia (FMD) revealed a promising novel disease gene and provided proof-of-concept for a protein/lipid-based FMD blood test. The role of NADPH oxidases in vascular physiology, and particularly endothelial cell differentiation, is highlighted with potential for cell therapy development. Imaging of vulnerable plaque has been an intense field of research. Features of plaque vulnerability on magnetic resonance imaging as an under-recognized cause of stroke are discussed. Major clinical trials on lower extremity peripheral artery disease have shown added benefit of dual antithrombotic (aspirin plus rivaroxaban) treatment.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Aortic Diseases / Peripheral Vascular Diseases / Biomedical Research Type of study: Diagnostic study / Prognostic study / Randomized controlled trials / Reviews / Systematic review of observational studies / Systematic review Limits: Animals / Humans Language: English Journal: Cardiovasc Res Year: 2021 Document Type: Article Affiliation country: Cvr

Full text: Available Collection: International databases Database: MEDLINE Main subject: Aortic Diseases / Peripheral Vascular Diseases / Biomedical Research Type of study: Diagnostic study / Prognostic study / Randomized controlled trials / Reviews / Systematic review of observational studies / Systematic review Limits: Animals / Humans Language: English Journal: Cardiovasc Res Year: 2021 Document Type: Article Affiliation country: Cvr