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Clinical Utility of Midregional Proadrenomedullin in Patients with COVID-19.
Lo Sasso, Bruna; Gambino, Caterina Maria; Scichilone, Nicola; Giglio, Rosaria Vincenza; Bivona, Giulia; Scazzone, Concetta; Muratore, Roberto; Milano, Salvatore; Barbagallo, Mario; Agnello, Luisa; Ciaccio, Marcello.
  • Lo Sasso B; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, Palermo, Italy.
  • Gambino CM; Department of Laboratory Medicine, AOUP P. Giaccone, Palermo, Italy.
  • Scichilone N; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, Palermo, Italy.
  • Giglio RV; Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
  • Bivona G; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, Palermo, Italy.
  • Scazzone C; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, Palermo, Italy.
  • Muratore R; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, Palermo, Italy.
  • Milano S; Department of Laboratory Medicine, AOUP P. Giaccone, Palermo, Italy.
  • Barbagallo M; Department of Laboratory Medicine, AOUP P. Giaccone, Palermo, Italy.
  • Agnello L; Department of Internal Medicine and Geriatrics, Geriatric Unit, University of Palermo, Italy.
  • Ciaccio M; Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, Palermo, Italy.
Lab Med ; 52(5): 493-498, 2021 Sep 01.
Article in English | MEDLINE | ID: covidwho-1526169
Semantic information from SemMedBD (by NLM)
1. proadrenomedullin TREATS COVID-19
Subject
proadrenomedullin
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TREATS
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COVID-19
2. COVID-19 PROCESS_OF Patients
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COVID-19
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8. Hospitalization TREATS Patients
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ABSTRACT

OBJECTIVE:

The aim of the study was to assess the role of midregional proadrenomedullin (MR-proADM) in patients with COVID-19.

METHODS:

We included 110 patients hospitalized for COVID-19. Biochemical biomarkers, including MR-proADM, were measured at admission. The association of plasma MR-proADM levels with COVID-19 severity, defined as a requirement for mechanical ventilation or in-hospital mortality, was evaluated.

RESULTS:

Patients showed increased levels of MR-proADM. In addition, MR-proADM was higher in patients who died during hospitalization than in patients who survived (median, 2.59 nmol/L; interquartile range, 2.3-2.95 vs median, 0.82 nmol/L; interquartile range, 0.57-1.03; P <.0001). Receiver operating characteristic curve analysis showed good accuracy of MR-proADM for predicting mortality. A MR-proADM value of 1.73 nmol/L was established as the best cutoff value, with 90% sensitivity and 95% specificity (P <.0001).

CONCLUSION:

We found that MR-proADM could represent a prognostic biomarker of COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Protein Precursors / Adrenomedullin / COVID-19 / Hypertension / Lung Diseases Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Lab Med Year: 2021 Document Type: Article Affiliation country: Labmed

Full text: Available Collection: International databases Database: MEDLINE Main subject: Protein Precursors / Adrenomedullin / COVID-19 / Hypertension / Lung Diseases Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Lab Med Year: 2021 Document Type: Article Affiliation country: Labmed