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Prime-Boost Vaccination With BNT162b2 Induces High Neutralizing Activity Against SARS-CoV-2 Variants in Naïve and COVID-19-Convalescent Individuals.
Luczkowiak, Joanna; Labiod, Nuria; Rivas, Gonzalo; Rolo, Marta; Lasala, Fátima; Lora-Tamayo, Jaime; Mancheno-Losa, Mikel; Rial, David; Pérez-Rivilla, Alfredo; Folgueira, María D; Delgado, Rafael.
  • Luczkowiak J; Instituto de Investigacion Hospital 12 de Octubre (imas12), Madrid, Spain.
  • Labiod N; Instituto de Investigacion Hospital 12 de Octubre (imas12), Madrid, Spain.
  • Rivas G; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Rolo M; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Lasala F; Instituto de Investigacion Hospital 12 de Octubre (imas12), Madrid, Spain.
  • Lora-Tamayo J; Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Mancheno-Losa M; Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Rial D; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Pérez-Rivilla A; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Folgueira MD; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Delgado R; Instituto de Investigacion Hospital 12 de Octubre (imas12), Madrid, Spain.
Open Forum Infect Dis ; 8(10): ofab468, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1526183
ABSTRACT

BACKGROUND:

The objective of this study was to investigate the neutralizing response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VoC) during coronavirus disease 2019 (COVID-19) convalescence and after vaccination.

METHODS:

COVID-19-convalescent and -naïve individuals were tested for neutralizing activity against SARS-CoV-2 VoC Alpha, Beta, Gamma, and Delta at 1 and 7 months postinfection and 4-6 weeks after BNT162b2 vaccination.

RESULTS:

Vaccination induced a high neutralizing response in naïve individuals. Interestingly, vaccination of convalescent patients induced a boosted response that was able to neutralize all VoC at high titers.

CONCLUSIONS:

Vaccination with BNT162b2 induced high levels of neutralization against SARS-CoV-2 VoC in most patients; this is especially beneficial in COVID-19-convalescent individuals.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid