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Six-month respiratory outcomes and exercise capacity of COVID-19 acute respiratory failure patients treated with continuous positive airway pressure.
Damanti, Sarah; Ramirez, Giuseppe Alvise; Bozzolo, Enrica Paola; Rovere-Querini, Patrizia; De Lorenzo, Rebecca; Magnaghi, Cristiano; Scotti, Raffaella; Di Lucca, Giuseppe; Marinosci, Alessandro; Strada, Silvia; Di Terlizzi, Gaetano; Vitali, Giordano; Martinenghi, Sabina; Compagnone, Nicola; Landoni, Giovanni; Tresoldi, Moreno.
  • Damanti S; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Ramirez GA; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Bozzolo EP; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Rovere-Querini P; Division of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • De Lorenzo R; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Magnaghi C; Division of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • Scotti R; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Di Lucca G; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Marinosci A; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Strada S; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Di Terlizzi G; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Vitali G; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Martinenghi S; Internal Medicine, Diabetes and Endocrinology Unit, San Raffaele Hospital and Scientific Institute, Milan, Italy.
  • Compagnone N; Internal Medicine, Diabetes and Endocrinology Unit, San Raffaele Hospital and Scientific Institute, Milan, Italy.
  • Landoni G; Diabetes Research Institute, San Raffaele Hospital and Scientific Institute, San Raffaele Vita Salute University, Milan, Italy.
  • Tresoldi M; Division of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Intern Med J ; 51(11): 1810-1815, 2021 11.
Article in English | MEDLINE | ID: covidwho-1526370
Semantic information from SemMedBD (by NLM)
1. Continuous Positive Airway Pressure TREATS Acute respiratory failure
Subject
Continuous Positive Airway Pressure
Predicate
TREATS
Object
Acute respiratory failure
2. Acute respiratory failure PROCESS_OF Patients
Subject
Acute respiratory failure
Predicate
PROCESS_OF
Object
Patients
3. Continuous Positive Airway Pressure TREATS Patients
Subject
Continuous Positive Airway Pressure
Predicate
TREATS
Object
Patients
4. Disease CAUSES Sequela of disorder
Subject
Disease
Predicate
CAUSES
Object
Sequela of disorder
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Continuous Positive Airway Pressure COEXISTS_WITH Hospitalization
Subject
Continuous Positive Airway Pressure
Predicate
COEXISTS_WITH
Object
Hospitalization
7. Dyspnea PROCESS_OF Patients
Subject
Dyspnea
Predicate
PROCESS_OF
Object
Patients
8. Frail PROCESS_OF Patients
Subject
Frail
Predicate
PROCESS_OF
Object
Patients
9. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
10. Performance PROCESS_OF Patients
Subject
Performance
Predicate
PROCESS_OF
Object
Patients
11. Continuous Positive Airway Pressure TREATS Acute respiratory failure
Subject
Continuous Positive Airway Pressure
Predicate
TREATS
Object
Acute respiratory failure
12. Acute respiratory failure PROCESS_OF Patients
Subject
Acute respiratory failure
Predicate
PROCESS_OF
Object
Patients
13. Continuous Positive Airway Pressure TREATS Patients
Subject
Continuous Positive Airway Pressure
Predicate
TREATS
Object
Patients
14. Disease CAUSES Sequela of disorder
Subject
Disease
Predicate
CAUSES
Object
Sequela of disorder
15. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
16. Continuous Positive Airway Pressure COEXISTS_WITH Hospitalization
Subject
Continuous Positive Airway Pressure
Predicate
COEXISTS_WITH
Object
Hospitalization
17. Dyspnea PROCESS_OF Patients
Subject
Dyspnea
Predicate
PROCESS_OF
Object
Patients
18. Frail PROCESS_OF Patients
Subject
Frail
Predicate
PROCESS_OF
Object
Patients
19. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
20. Performance PROCESS_OF Patients
Subject
Performance
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

BACKGROUND:

COVID-19 long-term sequelae are ill-defined since only a few studies have explored the long-term consequences of this disease so far.

AIMS:

To evaluate the 6-month respiratory outcome and exercise capacity of COVID-19 acute respiratory failure (ARF) patients treated with continuous positive airway pressure (CPAP) during the first wave of the ongoing COVID-19 pandemic.

METHODS:

A retrospective observational study included COVID-19 patients with ARF. Interventions included CPAP during hospitalisation and 6-month follow up. Frailty assessment was carried out through frailty index (FI), pO2 /FiO2 during hospitalisation and at follow up, respiratory parameters, 6-min walking test (6MWT) and the modified British Medical Research Council (mMRC) and Borg scale at follow up.

RESULTS:

More than half of the patients had no dyspnoea according to the mMRC scale. Lower in-hospital pO2 /FiO2 correlated with higher Borg scale levels after 6MWT (ρ 0.27; P 0.04) at the follow-up visit. FI was positively correlated with length of hospitalisation (ρ 0.3; P 0.03) and negatively with the 6MWT distance walked (ρ -0.36; P 0.004).

CONCLUSIONS:

Robust and frail patients with COVID-19 ARF treated with CPAP outside the intensive care unit setting had good respiratory parameters and exercise capacity at 6-month follow up, although more severe patients had slightly poorer respiratory performance compared with patients with higher PaO2 /FiO2 and lower FI.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Intern Med J Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Imj.15345

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Intern Med J Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Imj.15345