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Post-COVID-19 paediatric inflammatory multisystem syndrome: association of ethnicity, key worker and socioeconomic status with risk and severity.
Broad, Jonathan; Forman, Julia; Brighouse, James; Sobande, Adebola; McIntosh, Alysha; Watterson, Claire; Boot, Elizabeth; Montgomery, Felicity; Gilmour, Iona; Tan, Joy; Fogarty, Mary Johanna; Gomez, Xabier; Cheung, Ronny; Lillie, Jon; Shivamurthy, Vinay; Handforth, Jenny; Miller, Owen.
  • Broad J; Department of Paediatric Infectious Disease, Evelina London Children's Healthcare, London, UK jonathanb.broad@gmail.com.
  • Forman J; Kellogg College, University of Oxford, Oxford, UK.
  • Brighouse J; Department of Women and Children's Health, King's College London, London, UK.
  • Sobande A; Department of Paediatric Rheumatology, Evelina London Children's Healthcare, London, UK.
  • McIntosh A; Department of General Paediatrics, Evelina London Children's Healthcare, London, UK.
  • Watterson C; Department of Paediatric Infectious Disease, Evelina London Children's Healthcare, London, UK.
  • Boot E; Department of Paediatric Infectious Disease, Evelina London Children's Healthcare, London, UK.
  • Montgomery F; Department of Paediatric Intensive Care, Evelina London Children's Healthcare, London, UK.
  • Gilmour I; Department of General Paediatrics, Evelina London Children's Healthcare, London, UK.
  • Tan J; Department of General Paediatrics, Evelina London Children's Healthcare, London, UK.
  • Fogarty MJ; Department of General Paediatrics, Evelina London Children's Healthcare, London, UK.
  • Gomez X; Department of Paediatric Cardiology, Evelina London Children's Healthcare, London, UK.
  • Cheung R; Department of Paediatric Intensive Care, Evelina London Children's Healthcare, London, UK.
  • Lillie J; Department of General Paediatrics, Evelina London Children's Healthcare, London, UK.
  • Shivamurthy V; Department of Paediatric Intensive Care, Evelina London Children's Healthcare, London, UK.
  • Handforth J; Department of Paediatric Rheumatology, Evelina London Children's Healthcare, London, UK.
  • Miller O; Department of Paediatric Infectious Disease, Evelina London Children's Healthcare, London, UK.
Arch Dis Child ; 106(12): 1218-1225, 2021 12.
Article in English | MEDLINE | ID: covidwho-1526458
ABSTRACT

OBJECTIVES:

Patients from ethnic minority groups and key workers are over-represented among adults hospitalised or dying from COVID-19. In this population-based retrospective cohort, we describe the association of ethnicity, socioeconomic and family key worker status with incidence and severity of Paediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 (PIMS-TS).

SETTING:

Evelina London Children's Hospital (ELCH), the tertiary paediatric hospital for the South Thames Retrieval Service (STRS) region.

PARTICIPANTS:

70 children with PIMS-TS admitted 14 February 2020-2 June 2020. OUTCOME

MEASURES:

Incidence and crude ORs are presented, comparing ethnicity and socioeconomic status of our cohort and the catchment population, using census data and Index of Multiple Deprivation (IMD). Regression is used to estimate the association of ethnicity and IMD with admission duration and requirement for intensive care, inotropes and ventilation.

RESULTS:

Incidence was significantly higher in children from black (25.0 cases per 100 000 population), Asian (6.4/100 000) and other (17.8/100 000) ethnic groups, compared with 1.6/100 000 in white ethnic groups (ORs 15.7, 4.0 and 11.2, respectively). Incidence was higher in the three most deprived quintiles compared with the least deprived quintile (eg, 8.1/100 000 in quintile 1 vs 1.6/100 000 in quintile 5, OR 5.2). Proportions of families with key workers (50%) exceeded catchment proportions. Admission length of stay was 38% longer in children from black ethnic groups than white (95% CI 4% to 82%; median 8 days vs 6 days). 9/10 children requiring ventilation were from black ethnic groups.

CONCLUSIONS:

Children in ethnic minority groups, living in more deprived areas and in key worker families are over-represented. Children in black ethnic groups had longer admissions; ethnicity may be associated with ventilation requirement.This project was registered with the ELCH audit and service evaluation team, ref. no 11186.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Social Class / Ethnicity / Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Country/Region as subject: Europa Language: English Journal: Arch Dis Child Year: 2021 Document Type: Article Affiliation country: Archdischild-2020-320388

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Social Class / Ethnicity / Systemic Inflammatory Response Syndrome / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Country/Region as subject: Europa Language: English Journal: Arch Dis Child Year: 2021 Document Type: Article Affiliation country: Archdischild-2020-320388