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Impact of COVID-19 and lockdowns on pulmonary embolism in hospitalized patients in France: a nationwide study.
Tankere, Pierre; Cottenet, Jonathan; Tubert-Bitter, Pascale; Mariet, Anne-Sophie; Beltramo, Guillaume; Cadranel, Jacques; Piroth, Lionel; Bonniaud, Philippe; Quantin, Catherine.
  • Tankere P; Reference Center for Rare Pulmonary Diseases, Pulmonary Medicine and Intensive Care Unit Department, Dijon University Hospital, BP 77908, 21079, Dijon, France.
  • Cottenet J; CHU de Dijon - Service de Biostatistique et d'Informatique Médicale, BP 77908, 21079, Dijon CEDEX, France.
  • Tubert-Bitter P; University of Burgundy and Franche-Comté, Dijon, France.
  • Mariet AS; Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, High-Dimensional Biostatistics for Drug Safety and Genomics, CESP, Villejuif, France.
  • Beltramo G; CHU de Dijon - Service de Biostatistique et d'Informatique Médicale, BP 77908, 21079, Dijon CEDEX, France.
  • Cadranel J; University of Burgundy and Franche-Comté, Dijon, France.
  • Piroth L; Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Inserm, CIC 1432, Dijon, France ; Dijon University Hospital, Dijon, France.
  • Bonniaud P; Reference Center for Rare Pulmonary Diseases, Pulmonary Medicine and Intensive Care Unit Department, Dijon University Hospital, BP 77908, 21079, Dijon, France.
  • Quantin C; Chest Department and Constitutive Center for Rare Pulmonary Disease, Hôpital Tenon, AP-HP, Inflammation-Immunopathology-Biotherapy Department (DHU i2B) and Sorbonne Université, 75020, Paris, France.
Respir Res ; 22(1): 298, 2021 Nov 20.
Article in English | MEDLINE | ID: covidwho-1526637
ABSTRACT

BACKGROUND:

This study assessed the impact of the COVID-19 epidemic on overall hospitalizations for pulmonary embolism (PE) in France in comparison with previous years, and by COVID-19 and non-COVID-19 status.

METHODS:

Hospitalization data (2017-2020) were extracted from the French National Discharge database (all public and private hospitals). We included all patients older than 18 years hospitalized during the 3 years and extracted PE status and COVID-19 status (from March 2020). Age, sex and risk factors for PE (such as obesity, cancer) were identified. We also extracted transfer to an intensive care unit (ICU) and hospital death. The number of PE and the frequency of death in patients in 2019 and 2020 were described by month and by COVID-19 status. Logistic regressions were performed to identify the role of COVID-19 among other risk factors for PE in hospitalized patients.

RESULTS:

The overall number of patients hospitalized with PE increased by about 16% in 2020 compared with 2019, and mortality also increased to 10.3% (+ 1.2%). These increases were mostly linked to COVID-19 waves, which were associated with PE hospitalization in COVID-19 patients (PE frequency was 3.7%; 2.8% in non-ICU and 8.8% in ICU). The final PE odds ratio for COVID-19 hospitalized patients was 4 compared with other hospitalized patients in 2020. The analyses of PE in non-COVID-19 patients showed a 2.7% increase in 2020 compared with the previous three years.

CONCLUSION:

In 2020, the overall number of patients hospitalized with PE in France increased compared to the previous three years despite a considerable decrease in scheduled hospitalizations. Nevertheless, proactive public policy focused on the prevention of PE in all patients should be encouraged.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Communicable Disease Control / COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Respir Res Year: 2021 Document Type: Article Affiliation country: S12931-021-01887-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Communicable Disease Control / COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Respir Res Year: 2021 Document Type: Article Affiliation country: S12931-021-01887-6