Treatment of Catatonia with Asenapine in a Patient with Schizotypal Personality Disorder, Psychotic Depression and Septic Shock from SARSCoV- 2 - A Case Report.
CNS Neurol Disord Drug Targets
; 20(5): 473-477, 2021.
Article
in English
| MEDLINE | ID: covidwho-1526730
ABSTRACT
INTRODUCTION:
Catatonia is a psychomotor syndrome that presents with severe symptoms which can lead to dangerous and lethal conditions if not diagnosed and treated properly. SARS-- CoV-2 is a positive-sense single-stranded RNA virus that can occur in severe cases with acute pneumonia, ARDS, sepsis and septic shock. In these cases, ICU admission is necessary. CASESUMMARY:
A 59-year-old Caucasian man with septic shock and bilateral interstitial pneumonia from SARS-CoV-2 and schizotypal personality disorder presented with catatonic behaviour manifested by soporous state, response to intense painful stimuli with the opening of the eyes, execution of simple verbal commands, maintenance of the same position, catalepsy, immobility, rigidity and mutism. At the same time, there were symptoms of septic shock and catatonic symptoms, causing greater difficulty in the correct formulation of the diagnosis. During the course of his hospitalization, he was treated with asenapine 20 mg/day. The catatonia responded rapidly and significantly to the asenapine.DISCUSSION:
To date, the pathophysiology of catatonia is unclear, and few guidelines are available for the treatment of catatonia. In the literature, studies have reported the efficacy of benzodiazepines such as lorazepam and diazepam, GABAA agonists such as zolpidem, NMDA receptor antagonists such as memantine, antidepressant SSRIs such as fluoxetine and paroxetine, and antipsychotics such as olanzapine, clozapine and aripiprazole. We demonstrate that the antipsychotic asenapine is also effective in treating catatonic symptoms in psychiatric disorders.CONCLUSION:
Asenapine produced a rapid and significant reduction in catatonic symptoms in our patient with schizotypal personality disorder.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Schizotypal Personality Disorder
/
Shock, Septic
/
Antipsychotic Agents
/
Catatonia
/
Depressive Disorder, Major
/
Dibenzocycloheptenes
/
COVID-19
Type of study:
Case report
/
Prognostic study
/
Qualitative research
Topics:
Long Covid
Limits:
Humans
/
Male
/
Middle aged
Language:
English
Journal:
CNS Neurol Disord Drug Targets
Journal subject:
Neurology
/
Drug Therapy
Year:
2021
Document Type:
Article
Affiliation country:
1871527320666210226114238
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