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Maternal and Neonatal Outcomes of Critically Ill Pregnant and Puerperal Patients Diagnosed with COVID-19 Disease: Retrospective Comparative Study.
Eman, Ali; Balaban, Onur; Kocayigit, Havva; Süner, Kezban Özmen; Cirdi, Y; Erdem, Ali Fuat.
  • Eman A; Department of Anesthesiology and Reanimation, Sakarya Training and Research Hospital, Sakarya, Turkey. dralieman02@gmail.com.
  • Balaban O; Department of Anesthesiology and Reanimation, Sakarya University Faculty of Medicine, Training and Research Hospital, Sakarya, Turkey.
  • Kocayigit H; Department of Anesthesiology and Reanimation, Sakarya Training and Research Hospital, Sakarya, Turkey.
  • Süner KÖ; Department of Intensive Care, Sakarya Training and Research Hospital, Sakarya, Turkey.
  • Cirdi Y; Department of Intensive Care, Sakarya Training and Research Hospital, Sakarya, Turkey.
  • Erdem AF; Department of Anesthesiology and Reanimation, Sakarya University Faculty of Medicine, Training and Research Hospital, Sakarya, Turkey.
J Korean Med Sci ; 36(44): e309, 2021 Nov 15.
Article in English | MEDLINE | ID: covidwho-1593105
ABSTRACT

BACKGROUND:

We assessed maternal and neonatal outcomes of critically ill pregnant and puerperal patients in the clinical course of coronavirus disease 2019 (COVID-19).

METHODS:

Records of pregnant and puerperal women with polymerase chain reaction positive COVID-19 virus who were admitted to our intensive care unit (ICU) from March 2020 to August 2021 were investigated. Demographic, clinical and laboratory data, pharmacotherapy, and neonatal outcomes were analyzed. These outcomes were compared between patients that were discharged from ICU and patients who died in ICU.

RESULTS:

Nineteen women were included in this study. Additional oxygen was required in all cases (100%). Eight patients (42%) were intubated and mechanically ventilated. All patients that were mechanically ventilated have died. Increased levels of C-reactive protein (CRP) was seen in all patients (100%). D-dimer values increased in 15 patients (78.9%); interleukin-6 (IL-6) increased in 16 cases (84.2%). Sixteen patients used antiviral drugs. Eleven patients were discharged from the ICU and eight patients have died due to complications of COVID-19 showing an ICU mortality rate of 42.1%. Mean number of hospitalized days in ICU was significantly lower in patients that were discharged (P = 0.037). Seventeen patients underwent cesarean-section (C/S) (89.4%). Mean birth week was significantly lower in patients who died in ICU (P = 0.024). Eleven preterm (57.8%) and eight term deliveries (42.1%) occurred.

CONCLUSION:

High mortality rate was detected among critically ill pregnant/parturient patients followed in the ICU. Main predictors of mortality were the need of invasive mechanical ventilation and higher number of days hospitalized in ICU. Rate of C/S operations and preterm delivery were high. Pleasingly, the rate of neonatal death was low and no neonatal COVID-19 occurred.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pregnancy Complications, Infectious / Puerperal Disorders / SARS-CoV-2 / COVID-19 Subject: Pregnancy Complications, Infectious / Puerperal Disorders / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Language: English Journal: J Korean Med Sci Clinical aspect: Prediction / Prognosis / Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pregnancy Complications, Infectious / Puerperal Disorders / SARS-CoV-2 / COVID-19 Subject: Pregnancy Complications, Infectious / Puerperal Disorders / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Language: English Journal: J Korean Med Sci Clinical aspect: Prediction / Prognosis / Therapy Year: 2021
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