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Multi-Omics Approach in the Identification of Potential Therapeutic Biomolecule for COVID-19.
Singh, Rachana; Singh, Pradhyumna Kumar; Kumar, Rajnish; Kabir, Md Tanvir; Kamal, Mohammad Amjad; Rauf, Abdur; Albadrani, Ghadeer M; Sayed, Amany A; Mousa, Shaker A; Abdel-Daim, Mohamed M; Uddin, Md Sahab.
  • Singh R; Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Lucknow, India.
  • Singh PK; Plant Molecular Biology and Biotechnology Division, Council of Scientific and Industrial Research- National Botanical Research Institute (CSIR-NBRI), Lucknow, India.
  • Kumar R; Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Lucknow, India.
  • Kabir MT; Department of Pharmacy, Brac University, Dhaka, Bangladesh.
  • Kamal MA; West China School of Nursing/Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
  • Rauf A; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Albadrani GM; Enzymoics, Novel Global Community Educational Foundation, Hebersham, NSW, Australia.
  • Sayed AA; Department of Chemistry, University of Swabi, Khyber Pakhtunkhwa, Pakistan.
  • Mousa SA; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Abdel-Daim MM; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
  • Uddin MS; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, United States.
Front Pharmacol ; 12: 652335, 2021.
Article in English | MEDLINE | ID: covidwho-1526785
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
2. Vaccines TREATS 2019 novel coronavirus
Subject
Vaccines
Predicate
TREATS
Object
2019 novel coronavirus
3. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
4. Vaccines TREATS 2019 novel coronavirus
Subject
Vaccines
Predicate
TREATS
Object
2019 novel coronavirus
ABSTRACT
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has a disastrous effect on mankind due to the contagious and rapid nature of its spread. Although vaccines for SARS-CoV-2 have been successfully developed, the proven, effective, and specific therapeutic molecules are yet to be identified for the treatment. The repurposing of existing drugs and recognition of new medicines are continuously in progress. Efforts are being made to single out plant-based novel therapeutic compounds. As a result, some of these biomolecules are in their testing phase. During these efforts, the whole-genome sequencing of SARS-CoV-2 has given the direction to explore the omics systems and approaches to overcome this unprecedented health challenge globally. Genome, proteome, and metagenome sequence analyses have helped identify virus nature, thereby assisting in understanding the molecular mechanism, structural understanding, and disease propagation. The multi-omics approaches offer various tools and strategies for identifying potential therapeutic biomolecules for COVID-19 and exploring the plants producing biomolecules that can be used as biopharmaceutical products. This review explores the available multi-omics approaches and their scope to investigate the therapeutic promises of plant-based biomolecules in treating SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Topics: Vaccines Language: English Journal: Front Pharmacol Year: 2021 Document Type: Article Affiliation country: Fphar.2021.652335

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Topics: Vaccines Language: English Journal: Front Pharmacol Year: 2021 Document Type: Article Affiliation country: Fphar.2021.652335