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Systemic Inflammation and COVID-19 Mortality in Patients with Major Noncommunicable Diseases: Chronic Coronary Syndromes, Diabetes and Obesity.
Buicu, Andreea-Luciana; Cernea, Simona; Benedek, Imre; Buicu, Corneliu-Florin; Benedek, Theodora.
  • Buicu AL; Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mures, 540139 Târgu Mureș, Romania.
  • Cernea S; Department M3/Internal Medicine I, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mures, 38 Gheorghe Marinescu street, 540139 Târgu Mureș, Romania.
  • Benedek I; Diabetes, Nutrition and Metabolic Diseases Outpatient Unit, Emergency County Clinical Hospital, 540136 Târgu Mureș, Romania.
  • Buicu CF; Clinical Department of Internal Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mures, 540139 Târgu Mureș, Romania.
  • Benedek T; Clinic of Cardiology, Emergency County Clinical Hospital, 540136 Târgu Mureș, Romania.
J Clin Med ; 10(8)2021 Apr 07.
Article in English | MEDLINE | ID: covidwho-1526819
ABSTRACT
COVID-19 is currently considered an inflammatory disease affecting the entire organism. In severe forms, an augmented inflammatory response leads to the fulminant "cytokine storm", which may result in severe multisystemic end-organ damage. Apart from the acute inflammatory response, it seems that chronic inflammation also plays a major role in the clinical evolution of COVID-19 patients. Pre-existing inflammatory conditions, such as those associated with chronic coronary diseases, type 2 diabetes mellitus or obesity, may be associated with worse clinical outcomes in the context of COVID-19 disease. These comorbidities are reported as powerful predictors of poor outcomes and death following COVID-19 disease. Moreover, in the context of chronic coronary syndrome, the cytokine storm triggered by SARS-CoV-2 infection may favor vulnerabilization and rupture of a silent atheromatous plaque, with consequent acute coronary syndrome, leading to a sudden deterioration of the clinical condition of the patient. This review aims to present the current status of knowledge regarding the link between COVID-19 mortality, systemic inflammation and several major diseases associated with poor outcomes, such as cardiovascular diseases, diabetes and obesity.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10081545

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10081545