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Admission High-Sensitive Cardiac Troponin T Level Increase Is Independently Associated with Higher Mortality in Critically Ill Patients with COVID-19: A Multicenter Study.
Larcher, Romaric; Besnard, Noemie; Akouz, Aziz; Rabier, Emmanuelle; Teule, Lauranne; Vandercamere, Thomas; Zozor, Samuel; Amalric, Matthieu; Benomar, Racim; Brunot, Vincent; Corne, Philippe; Barbot, Olivier; Dupuy, Anne-Marie; Cristol, Jean-Paul; Klouche, Kada.
  • Larcher R; Biochemistry and Hormonology Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
  • Besnard N; PhyMedExp, University of Montpellier, INSERM, CNRS, Arnaud de Villeneuve Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
  • Akouz A; Intensive Care Medicine Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
  • Rabier E; Intensive Care Unit, Hospital of Perpignan, 66000 Perpignan, France.
  • Teule L; Intensive Care Unit, Hospital of Narbonne, 11100 Narbonne, France.
  • Vandercamere T; Intensive Care Unit, Hospital of Perpignan, 66000 Perpignan, France.
  • Zozor S; Intensive Care Unit, Hospital of Narbonne, 11100 Narbonne, France.
  • Amalric M; Biochemistry and Hormonology Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
  • Benomar R; Intensive Care Medicine Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
  • Brunot V; Intensive Care Medicine Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
  • Corne P; Intensive Care Medicine Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
  • Barbot O; Intensive Care Medicine Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
  • Dupuy AM; Intensive Care Unit, Hospital of Perpignan, 66000 Perpignan, France.
  • Cristol JP; Biochemistry and Hormonology Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
  • Klouche K; Biochemistry and Hormonology Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.
J Clin Med ; 10(8)2021 Apr 13.
Article in English | MEDLINE | ID: covidwho-1526835
ABSTRACT

BACKGROUND:

In coronavirus disease 2019 (COVID-19) patients, increases in high-sensitive cardiac troponin T (hs-cTnT) have been reported to be associated with worse outcomes. In the critically ill, the prognostic value of hs-cTnT, however, remains to be assessed given that most previous studies have involved a case mix of non- and severely ill COVID-19 patients.

METHODS:

We conducted, from March to May 2020, in three French intensive care units (ICUs), a multicenter retrospective cohort study to assess in-hospital mortality predictability of hs-cTnT levels in COVID-19 patients.

RESULTS:

111 laboratory-confirmed COVID-19 patients (68% of male, median age 67 (58-75) years old) were included. At ICU admission, the median Charlson Index, Simplified Acute Physiology Score II, and PaO2/FiO2 were at 3 (2-5), 37 (27-48), and 140 (98-154), respectively, and the median hs-cTnT serum levels were at 16.0 (10.1-31.9) ng/L. Seventy-five patients (68%) were mechanically ventilated, 41 (37%) were treated with norepinephrine, and 17 (15%) underwent renal replacement therapy. In-hospital mortality was 29% (32/111) and was independently associated with lower PaO2/FiO2 and higher hs-cTnT serum levels.

CONCLUSIONS:

At ICU admission, besides PaO2/FiO2, hs-cTnT levels may allow early risk stratification and triage in critically ill COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10081656

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10081656