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Seroprevalence of Antibodies against SARS-CoV-2 in Children with Juvenile Idiopathic Arthritis a Case-Control Study.
Opoka-Winiarska, Violetta; Grywalska, Ewelina; Korona-Glowniak, Izabela; Matuska, Katarzyna; Malm, Anna; Rolinski, Jacek.
  • Opoka-Winiarska V; Department of Paediatric Pulmonology and Rheumatology, Medical University of Lublin, Gebali 6, 20-093 Lublin, Poland.
  • Grywalska E; Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland.
  • Korona-Glowniak I; Department of Pharmaceutical Microbiology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland.
  • Matuska K; Department of Diagnostic Microbiology, Independent Public Teaching Hospital No 1, Staszica 16, 20-081 Lublin, Poland.
  • Malm A; Department of Pharmaceutical Microbiology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland.
  • Rolinski J; Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland.
J Clin Med ; 10(8)2021 Apr 19.
Article in English | MEDLINE | ID: covidwho-1526843
ABSTRACT
There is limited data on the effect of the novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) on pediatric rheumatology. We examined the prevalence of antibodies against SARS-CoV-2 in children with juvenile idiopathic arthritis (JIA) and a negative history of COVID-19 and the correlation of the presence of these antibodies with disease activity measured by juvenile arthritis disease activity score (JADAS). In total, 62 patients diagnosed with JIA, under treatment with various antirheumatic drugs, and 32 healthy children (control group) were included. Serum samples were analyzed for inflammatory markers and antibodies and their state evaluated with the juvenile arthritis disease activity score (JADAS). JIA patients do not have a higher seroprevalence of anti-SARS-CoV-2 antibodies than healthy subjects. We found anti-SARS-CoV-2 antibodies in JIA patients who did not have a history of COVID-19. The study showed no unequivocal correlation between the presence of SARS-CoV-2 antibodies and JIA activity; therefore, this relationship requires further observation. We also identified a possible link between patients' humoral immune response and disease-modifying antirheumatic treatment, which will be confirmed in follow-up studies.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Observational study / Prognostic study / Risk factors Language: English Clinical aspect: Prognosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Observational study / Prognostic study / Risk factors Language: English Clinical aspect: Prognosis Year: 2021
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