Your browser doesn't support javascript.
Hydrogen peroxide as an auxiliary treatment for COVID-19 in Brazil: a randomized double-blind clinical trial.
Domênico, Marielle Bazzo Di; Collares, Kauê; Santos, Renan Brandenburg Dos; Lenz, Ulysses; Antunes, Vinícius Picoli; Godinho, Vinicius Webber; Cesca, Henrique; Ponciano, Thales Henrique Jincziwski; Corazza, Pedro Henrique.
  • Domênico MBD; Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil.
  • Collares K; Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil.
  • Santos RBD; Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil.
  • Lenz U; Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil.
  • Antunes VP; Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil.
  • Godinho VW; Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil.
  • Cesca H; Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil.
  • Ponciano THJ; Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil.
  • Corazza PH; Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil.
Epidemiol Health ; 43: e2021051, 2021.
Article in English | MEDLINE | ID: covidwho-1526916
ABSTRACT

OBJECTIVES:

This study evaluated the effectiveness of hydrogen peroxide (H2O2) as mouthwash and nasal spray on symptom relief in coronavirus disease 2019 (COVID-19) patients.

METHODS:

Patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), who were treated in a hospital or at home, and patients' family members (not positive for SARS-CoV-2), were randomized into 2 groups experimental (1% H2O2 for gargling, 0.5% H2O2 for nasal wash), and control. Patients gargled the solution 3 times a day, and applied the nasal spray twice a day, for a 7-day period. Family members received the same treatment as the treated COVID-19 patient. The researchers contacted patients every 2 days over an 8-day period. An average post-treatment interval of 8 days passed before testing family members.

RESULTS:

The most frequent symptoms on day 0 were cough, loss of taste, and hyposmia; there were no significant differences between groups, independent of the period. The symptom of dyspnea presented a significant difference between days 2 and 4 (p<0.05). Among family members, 86.0% had no antibodies, 2.3% had antibodies, and 11.6% had active infections (4 in the experimental group and 6 in the control group). The most frequent adverse effects in the H2O2 group were a burning throat and nose.

CONCLUSIONS:

H2O2 was not effective for the relief of COVID-19 symptoms and was associated with reports of transient adverse effects.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hydrogen Peroxide Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Epidemiol Health Year: 2021 Document Type: Article Affiliation country: Epih.e2021051

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hydrogen Peroxide Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Epidemiol Health Year: 2021 Document Type: Article Affiliation country: Epih.e2021051