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Cerebrospinal Fluid Analysis Post-COVID-19 Is Not Suggestive of Persistent Central Nervous System Infection.
Schweitzer, Finja; Goereci, Yasemin; Franke, Christiana; Silling, Steffi; Bösl, Fabian; Maier, Franziska; Heger, Eva; Deiman, Birgit; Prüss, Harald; Onur, Oezguer A; Klein, Florian; Fink, Gereon R; Di Cristanziano, Veronica; Warnke, Clemens.
  • Schweitzer F; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Goereci Y; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Franke C; Department of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Free University of Berlin, Humboldt University of Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Silling S; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Bösl F; Department of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Free University of Berlin, Humboldt University of Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Maier F; Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Heger E; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Deiman B; Clinical Laboratory, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.
  • Prüss H; Institute for Complex Molecular Systems and Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, Eindhoven, the Netherlands.
  • Onur OA; Expert Center Clinical Chemistry Eindhoven, Eindhoven, the Netherlands.
  • Klein F; Department of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Free University of Berlin, Humboldt University of Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Fink GR; German Center for Neurodegenerative Diseases Berlin, Berlin, Germany.
  • Di Cristanziano V; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Warnke C; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany.
Ann Neurol ; 91(1): 150-157, 2022 01.
Article in English | MEDLINE | ID: covidwho-1527416
ABSTRACT
This study was undertaken to assess whether SARS-CoV-2 causes a persistent central nervous system infection. SARS-CoV-2-specific antibody index and SARS-CoV-2 RNA were studied in cerebrospinal fluid following COVID-19. Cerebrospinal fluid was assessed between days 1 and 30 (n = 12), between days 31 and 90 (n = 8), or later than 90 days (post-COVID-19, n = 20) after COVID-19 diagnosis. SARS-CoV-2 RNA was absent in all patients, and in none of the 20 patients with post-COVID-19 syndrome were intrathecally produced anti-SARS-CoV-2 antibodies detected. The absence of evidence of SARS-CoV-2 in cerebrospinal fluid argues against a persistent central nervous system infection as a cause of neurological or neuropsychiatric post-COVID-19 syndrome. ANN NEUROL 2022;91150-157.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Central Nervous System Infections / COVID-19 Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Ann Neurol Year: 2022 Document Type: Article Affiliation country: Ana.26262

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Central Nervous System Infections / COVID-19 Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Ann Neurol Year: 2022 Document Type: Article Affiliation country: Ana.26262