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Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 - A case series.
Wang, Changsong; Kang, Kai; Lan, Xiuwen; Fei, Dongsheng; Wang, Qian; Li, Xianyong; Chong, Yang; Gao, Yan; Wang, Huaiquan; Li, Xueting; Zhao, Mingyan; Yu, Kaijiang.
  • Wang C; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China; Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
  • Kang K; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China.
  • Lan X; Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
  • Fei D; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China.
  • Wang Q; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China; Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
  • Li X; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China.
  • Chong Y; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China.
  • Gao Y; Department of Critical Care Medicine, The Fourth Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
  • Wang H; Department of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
  • Li X; Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
  • Zhao M; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China. Electronic address: mingyan1970@163.com.
  • Yu K; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China. Electronic address: drkaijiang@163.com.
J Infect ; 83(5): e6-e9, 2021 11.
Article in English | MEDLINE | ID: covidwho-1527752
ABSTRACT

PURPOSE:

To describe the relationship between the severity of lung damage and cytokine levels in sputum, bronchoalveolar lavage fluid (BALF), serum.

METHOD:

Eight severe patients infected with coronavirus disease 2019 (COVID-19) were admitted and their cytokines and chest computed tomography (CT) were analyzed.

RESULTS:

Compared with in serum, IL-6 and TNF-α in sputum and in BALF show more directly reflect the severity of COVID-19 critical patients. The gradient ratio of IL-6 levels may predict the prognosis of severe patients.

CONCLUSION:

Cytokine levels in the sputum may be more helpful for indicating lung damage. Local intervention through the respiratory tract is expected to benefit patients with severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sputum / Cytokines / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.jinf.2021.08.026

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sputum / Cytokines / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.jinf.2021.08.026