Your browser doesn't support javascript.
Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility.
Viveiros, Anissa; Gheblawi, Mahmoud; Aujla, Preetinder K; Sosnowski, Deanna K; Seubert, John M; Kassiri, Zamaneh; Oudit, Gavin Y.
  • Viveiros A; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.
  • Gheblawi M; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
  • Aujla PK; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
  • Sosnowski DK; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
  • Seubert JM; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada; Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
  • Kassiri Z; Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
  • Oudit GY; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada; Division of Cardiology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address: gavin.oudit@ualberta.ca.
J Mol Cell Cardiol ; 164: 13-16, 2022 03.
Article in English | MEDLINE | ID: covidwho-1527886
ABSTRACT
Aged males disproportionately succumb to increased COVID-19 severity, hospitalization, and mortality compared to females. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2) facilitate SARS-CoV-2 viral entry and may have sexually dimorphic regulation. As viral load dictates disease severity, we investigated the expression, protein levels, and activity of ACE2 and TMPRSS2. Our data reveal that aged males have elevated ACE2 in both mice and humans across organs. We report the first comparative study comprehensively investigating the impact of sex and age in murine and human levels of ACE2 and TMPRSS2, to begin to elucidate the sex bias in COVID-19 severity.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Aging / Gene Expression Regulation, Enzymologic / Sex Characteristics / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Animals / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Mol Cell Cardiol Year: 2022 Document Type: Article Affiliation country: J.yjmcc.2021.11.003

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Aging / Gene Expression Regulation, Enzymologic / Sex Characteristics / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Adult / Animals / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Mol Cell Cardiol Year: 2022 Document Type: Article Affiliation country: J.yjmcc.2021.11.003