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Virus Isolation from the First Patient with SARS-CoV-2 in Korea.
Park, Wan Beom; Kwon, Nak Jung; Choi, Su Jin; Kang, Chang Kyung; Choe, Pyoeng Gyun; Kim, Jin Yong; Yun, Jiyoung; Lee, Gir Won; Seong, Moon Woo; Kim, Nam Joong; Seo, Jeong Sun; Oh, Myoung Don.
  • Park WB; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • Kwon NJ; Laboratory of Infection & Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
  • Choi SJ; Macrogen Inc., Seoul, Korea.
  • Kang CK; Laboratory of Infection & Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
  • Choe PG; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • Kim JY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • Yun J; Department of Internal Medicine, Incheon Medical Center, Incheon, Korea.
  • Lee GW; Macrogen Inc., Seoul, Korea.
  • Seong MW; Macrogen Inc., Seoul, Korea.
  • Kim NJ; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • Seo JS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • Oh MD; Laboratory of Infection & Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
J Korean Med Sci ; 35(7): e84, 2020 Feb 24.
Article in English | MEDLINE | ID: covidwho-1528
ABSTRACT
Novel coronavirus (SARS-CoV-2) is found to cause a large outbreak started from Wuhan since December 2019 in China and SARS-CoV-2 infections have been reported with epidemiological linkage to China in 25 countries until now. We isolated SARS-CoV-2 from the oropharyngeal sample obtained from the patient with the first laboratory-confirmed SARS-CoV-2 infection in Korea. Cytopathic effects of SARS-CoV-2 in the Vero cell cultures were confluent 3 days after the first blind passage of the sample. Coronavirus was confirmed with spherical particle having a fringe reminiscent of crown on transmission electron microscopy. Phylogenetic analyses of whole genome sequences showed that it clustered with other SARS-CoV-2 reported from Wuhan.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oropharynx / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Whole Genome Sequencing Type of study: Case report / Diagnostic study / Randomized controlled trials Limits: Adult / Female / Humans Country/Region as subject: Asia Language: English Journal: J Korean Med Sci Journal subject: Medicine Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oropharynx / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Whole Genome Sequencing Type of study: Case report / Diagnostic study / Randomized controlled trials Limits: Adult / Female / Humans Country/Region as subject: Asia Language: English Journal: J Korean Med Sci Journal subject: Medicine Year: 2020 Document Type: Article