Human bronchial-pulmonary proteomics in coronavirus disease 2019 (COVID-19) pandemic: applications and implications.
Expert Rev Proteomics
; 18(11): 925-938, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1528086
ABSTRACT
INTRODUCTION:
The outbreak of the newly discovered human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has disrupted the normal life of almost every civilization worldwide. Studies have shown that the coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 can affect multiple human organs and physiological systems, but the respiratory system remains the primary location for viral infection. AREAS COVERED We summarize how omics technologies are used in SARS-CoV-2 research and specifically review the current knowledge of COVID-19 from the aspect of human bronchial-pulmonary proteomics. Also, knowledge gaps in COVID-19 that can be fulfilled by proteomics are discussed. EXPERT OPINION Overall, human bronchial-pulmonary proteomics plays an important role in revealing the dynamics, functions, tropism, and pathogenicity of SARS-CoV-2, which is crucial for COVID-19 biomarker and therapeutic target discoveries. To more fully understand the impact of COVID-19, research from various angles using multi-omics approaches should also be conducted on the lungs as well as other organs.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Bronchi
/
Proteomics
/
Pandemics
/
SARS-CoV-2
/
COVID-19
/
Lung
Limits:
Animals
/
Humans
Language:
English
Journal:
Expert Rev Proteomics
Journal subject:
Biochemistry
Year:
2021
Document Type:
Article
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