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Acquired Thrombotic Thrombocytopenic Purpura Following BNT162b2 mRNA Coronavirus Disease Vaccination in a Japanese Patient.
Yoshida, Kikuaki; Sakaki, Ayaka; Matsuyama, Yoriko; Mushino, Toshiki; Matsumoto, Masanori; Sonoki, Takashi; Tamura, Shinobu.
  • Yoshida K; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Sakaki A; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Matsuyama Y; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Mushino T; Department of General Internal Medicine, Hashimoto Municipal Hospital, Japan.
  • Matsumoto M; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Sonoki T; Department of Blood Transfusion Medicine, Nara Medical University, Japan.
  • Tamura S; Department of Hematology/Oncology, Wakayama Medical University, Japan.
Intern Med ; 61(3): 407-412, 2022 Feb 01.
Article in English | MEDLINE | ID: covidwho-1666883
ABSTRACT
A 57-year-old man without underlying diseases presented with fatigue, loss of appetite, and jaundice 1 week after receiving the first dose of the BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccine and showed hemolytic anemia with fragmented erythrocytes and severe thrombocytopenia 2 weeks after receiving the vaccine. An a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13 (ADAMTS13) activity level of <10% and ADAMTS13 inhibitor positivity confirmed the diagnosis of acquired thrombotic thrombocytopenic purpura (TTP). Combination therapy with plasma exchange, corticosteroid, and rituximab improved the clinical outcome. We herein report the first Japanese case of TTP possibly associated with vaccination. Physicians should be alert for this rare but life-threatening hematological complication following COVID-19 vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Purpura, Thrombotic Thrombocytopenic / COVID-19 / BNT162 Vaccine Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Vaccines Limits: Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: INTERNALMEDICINE.8568-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Purpura, Thrombotic Thrombocytopenic / COVID-19 / BNT162 Vaccine Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Vaccines Limits: Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: INTERNALMEDICINE.8568-21