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A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study.
Würstle, Silvia; Erber, Johanna; Hanselmann, Michael; Hoffmann, Dieter; Werfel, Stanislas; Hering, Svenja; Weidlich, Simon; Schneider, Jochen; Franke, Ralf; Maier, Michael; Henkel, Andreas G; Schmid, Roland M; Protzer, Ulrike; Laxy, Michael; Spinner, Christoph D.
  • Würstle S; Department of Internal Medicine II, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
  • Erber J; Department of Internal Medicine II, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
  • Hanselmann M; Department for Sport and Health Sciences, Professorship of Public Health and Prevention, Technical University of Munich, Munich, Germany.
  • Hoffmann D; School of Medicine / Helmholtz Zentrum München, Institute of Virology, Technical University of Munich, Munich, Germany.
  • Werfel S; Department of Nephrology, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
  • Hering S; School of Medicine / Helmholtz Zentrum München, Institute of Virology, Technical University of Munich, Munich, Germany.
  • Weidlich S; Department of Internal Medicine II, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
  • Schneider J; Department of Internal Medicine II, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
  • Franke R; Siemens AG, Munich, Germany.
  • Maier M; Siemens AG, Munich, Germany.
  • Henkel AG; Department of Information Technology, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
  • Schmid RM; Department of Internal Medicine II, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
  • Protzer U; School of Medicine / Helmholtz Zentrum München, Institute of Virology, Technical University of Munich, Munich, Germany.
  • Laxy M; German Centre for Infection Research (DZIF), Partner site, Munich, Germany.
  • Spinner CD; Department for Sport and Health Sciences, Professorship of Public Health and Prevention, Technical University of Munich, Munich, Germany.
JMIR Form Res ; 6(1): e32564, 2022 Jan 04.
Article in English | MEDLINE | ID: covidwho-1528774
ABSTRACT

BACKGROUND:

Large-scale, polymerase chain reaction (PCR)-based SARS-CoV-2 testing is expensive, resource intensive, and time consuming. A self-collection approach is a probable alternative; however, its feasibility, cost, and ability to prevent infections need to be evaluated.

OBJECTIVE:

This study aims to compare an innovative self-collection approach with a regular SARS-CoV-2 testing strategy in a large European industrial manufacturing site.

METHODS:

The feasibility of a telemedicine-guided PCR-based self-collection approach was assessed for 150 employees (intervention group) and compared with a regular SARS-CoV-2 testing approach used for 143 employees (control group). Acceptance, ergonomics, and efficacy were evaluated using a software application. A simulation model was implemented to evaluate the effectiveness. An interactive R shiny app was created to enable customized simulations.

RESULTS:

The test results were successfully communicated to and interpreted without uncertainty by 76% (114/150) and 76.9% (110/143) of the participants in the intervention and control groups, respectively (P=.96). The ratings for acceptability, ergonomics, and efficacy among intervention group participants were noninferior when compared to those among control group participants (acceptability 71.6% vs 37.6%; ergonomics 88.1% vs 74.5%; efficacy 86.4% vs 77.5%). The self-collection approach was found to be less time consuming (23 min vs 38 min; P<.001). The simulation model indicated that both testing approaches reduce the risk of infection, and the self-collection approach tends to be slightly less effective owing to its lower sensitivity.

CONCLUSIONS:

The self-collection approach for SARS-CoV-2 diagnosis was found to be technically feasible and well rated in terms of acceptance, ergonomics, and efficacy. The simulation model facilitates the evaluation of test effectiveness; nonetheless, considering context specificity, appropriate adaptation by companies is required.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Randomized controlled trials Language: English Journal: JMIR Form Res Year: 2022 Document Type: Article Affiliation country: 32564

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Randomized controlled trials Language: English Journal: JMIR Form Res Year: 2022 Document Type: Article Affiliation country: 32564