Your browser doesn't support javascript.
Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape.
Lou, Fuxing; Li, Maochen; Pang, Zehan; Jiang, Lin; Guan, Lin; Tian, Lili; Hu, Jiaming; Fan, Junfen; Fan, Huahao.
  • Lou F; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
  • Li M; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
  • Pang Z; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
  • Jiang L; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
  • Guan L; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
  • Tian L; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
  • Hu J; Tandon School of Engineering, New York University, New York, NY, United States.
  • Fan J; Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
  • Fan H; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Front Immunol ; 12: 744242, 2021.
Article in English | MEDLINE | ID: covidwho-1528819
ABSTRACT
The global pandemic of the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), places a heavy burden on global public health. Four SARS-CoV-2 variants of concern including B.1.1.7, B.1.351, B.1.617.2, and P.1, and two variants of interest including C.37 and B.1.621 have been reported to have potential immune escape, and one or more mutations endow them with worrisome epidemiologic, immunologic, or pathogenic characteristics. This review introduces the latest research progress on SARS-CoV-2 variants of interest and concern, key mutation sites, and their effects on virus infectivity, mortality, and immune escape. Moreover, we compared the effects of various clinical SARS-CoV-2 vaccines and convalescent sera on epidemic variants, and evaluated the neutralizing capability of several antibodies on epidemic variants. In the end, SARS-CoV-2 evolution strategies in different transmission stages, the impact of different vaccination strategies on SARS-CoV-2 immune escape, antibody therapy strategies and COVID-19 epidemic control prospects are discussed. This review will provide a systematic and comprehensive understanding of the secret of SARS-CoV-2 variants of interest/concern and immune escape.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immune Evasion / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.744242

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Immune Evasion / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.744242