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AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection.
Spinicci, Michele; Mazzoni, Alessio; Borchi, Beatrice; Graziani, Lucia; Mazzetti, Marcello; Bartalesi, Filippo; Botta, Annarita; Tilli, Marta; Pieralli, Filippo; Coppi, Marco; Giovacchini, Nicla; Colao, Maria Grazia; Saccardi, Riccardo; Rossolini, Gian Maria; Annunziato, Francesco; Bartoloni, Alessandro.
  • Spinicci M; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Mazzoni A; Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
  • Borchi B; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Graziani L; Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
  • Mazzetti M; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Bartalesi F; Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
  • Botta A; Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
  • Tilli M; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Pieralli F; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Coppi M; Intermediate Care Unit, Careggi University Hospital, Florence, Italy.
  • Giovacchini N; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Colao MG; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Saccardi R; Microbiology and Virology Unit, Careggi University Hospital, Florence, Italy.
  • Rossolini GM; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Annunziato F; Department of Cellular Therapies and Transfusion Medicine, Careggi University Hospital, Florence, Italy.
  • Bartoloni A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Eur J Immunol ; 52(2): 352-355, 2022 02.
Article in English | MEDLINE | ID: covidwho-1530141
ABSTRACT
A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Acquired Immunodeficiency Syndrome / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: Eur J Immunol Year: 2022 Document Type: Article Affiliation country: Eji.202149574

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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Acquired Immunodeficiency Syndrome / CD8-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 Type of study: Case report / Observational study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: Eur J Immunol Year: 2022 Document Type: Article Affiliation country: Eji.202149574