Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: A cross-sectional study.
Obesity (Silver Spring)
; 30(1): 165-171, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1530202
ABSTRACT
OBJECTIVE:
The aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID-19.METHODS:
A total of 109 hospitalized COVID-19 patients in noncritical status were cross-sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C-reactive protein, ferritin, D-dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow-mediated dilation (FMD) method.RESULTS:
The sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI -0.26 to -0.11; p < 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI -1.77 to -0.29; p = 0.007) and blood levels of creatinine (95% CI -1.99 to -0.16; p = 0.022).CONCLUSIONS:
Increased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Obesity (Silver Spring)
Journal subject:
Nutritional Sciences
/
Physiology
/
Metabolism
Year:
2022
Document Type:
Article
Affiliation country:
Oby.23311
Similar
MEDLINE
...
LILACS
LIS