IFN-&#945;2a Therapy in Two Patients with Inborn Errors of TLR3 and IRF3 Infected with SARS-CoV-2.

Lévy, Romain; Bastard, Paul; Lanternier, Fanny; Lecuit, Marc; Zhang, Shen-Ying; Casanova, Jean-Laurent

IFN-α2a Therapy in Two Patients with Inborn Errors of TLR3 and IRF3 Infected with SARS-CoV-2.

Lévy, Romain; Bastard, Paul; Lanternier, Fanny; Lecuit, Marc; Zhang, Shen-Ying; Casanova, Jean-Laurent.

Lévy R; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. romain.levy@inserm.fr.
Bastard P; University of Paris, Imagine Institute, Paris, France. romain.levy@inserm.fr.
Lanternier F; Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France. romain.levy@inserm.fr.
Lecuit M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Zhang SY; University of Paris, Imagine Institute, Paris, France.
Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.

J Clin Immunol ; 41(1): 26-27, 2021 01.

Article in English | MEDLINE | ID: covidwho-1530354

Subject(s)

COVID-19 Drug Treatment; Interferon Regulatory Factor-3/deficiency; Interferon-alpha/therapeutic use; Polyethylene Glycols/therapeutic use; Primary Immunodeficiency Diseases/immunology; Toll-Like Receptor 3/deficiency; Adult; COVID-19/diagnosis; COVID-19/immunology; COVID-19/virology; Female; Humans; Interferon Regulatory Factor-3/genetics; Interferon Type I/immunology; Interferon Type I/metabolism; Primary Immunodeficiency Diseases/complications; Primary Immunodeficiency Diseases/genetics; Recombinant Proteins/therapeutic use; SARS-CoV-2/immunology; SARS-CoV-2/isolation & purification; Toll-Like Receptor 3/genetics; Treatment Outcome

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polyethylene Glycols / Interferon-alpha / Interferon Regulatory Factor-3 / Toll-Like Receptor 3 / Primary Immunodeficiency Diseases / COVID-19 Drug Treatment Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: J Clin Immunol Year: 2021 Document Type: Article Affiliation country: S10875-020-00933-0

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