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The Influence of COVID-19 on the Stability of Patients with Neovascular Age-Related Macular Degeneration with Different Treatment Regimens.
Jiang, Bo; Gao, Lin; Dong, Su; Hou, Qingxue; Sun, Minghao; Zhang, Jingjie; Yu, Haotian; Zhang, Zhongyu; Sun, Dawei.
  • Jiang B; Ophthalmology Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China.
  • Gao L; Ophthalmology Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China.
  • Dong S; Ophthalmology Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China.
  • Hou Q; Ophthalmology Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China.
  • Sun M; Ophthalmology Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China.
  • Zhang J; Ophthalmology Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China.
  • Yu H; Ophthalmology Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China.
  • Zhang Z; Ophthalmology Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China.
  • Sun D; Ophthalmology Department, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China. sun.dawei@hotmail.com.
Adv Ther ; 39(4): 1568-1581, 2022 04.
Article in English | MEDLINE | ID: covidwho-1530424
ABSTRACT

INTRODUCTION:

To explore the impact of coronavirus disease 2019 (COVID-19) on the stability of patients with neovascular age-related macular degeneration (nAMD) receiving the treat and extend (T&E) or the pro re nata (PRN) treatment regimen and to identify indicators that may predict the disease stability of nAMD.

METHODS:

This is a retrospective study of patients with nAMD treated at the Second Affiliated Hospital of Harbin Medical University whose treatment schedule was interrupted at least once between 1 February and 31 May 2020. The demographic and clinical characteristics, including the best corrected visual acuity (BCVA), optical coherence tomography (OCT) features, subfoveal choroidal thickness (SFCT), interval between the last injection and the beginning of the pandemic, and the number of anti-vascular endothelial growth factor (VEGF) injections, were analyzed.

RESULTS:

A total of 209 stable patients with nAMD (122 eyes received the T&E regimen; 87 eyes received the PRN regimen) were identified. Compared to those who received the PRN regimen, the patients who received the T&E regimen were more stable during the first visit after COVID-19 (53.3% vs. 33.3%, P = 0.004), the BCVA was significantly better (58.5 letters vs. 56 letters, P = 0.006), and the CRT fluctuated only slightly (15 µm vs. 35 µm, P = 0.001). Furthermore, a multivariate logistic regression analysis showed that stable patients with nAMD with type 1 choroidal neovascularization (CNV) (OR 2.493 [95% CI 1.179-5.272], compared with type 2 CNV; P = 0.017; OR 2.912 [95% CI 1.133-7.485], compared with retinal angiomatous proliferation; P = 0.026) or with pigment epithelial detachment (PED) were more likely to remain stable when treatment was interrupted (OR 0.392 [95% CI 0.181-0.852], compared with no PED; P = 0.018).

CONCLUSION:

Compared to patients who received the PRN treatment regimen, stable patients with nAMD who received the T&E treatment regimen could better maintain stability when the treatments were suddenly interrupted by the COVID-19 pandemic. In addition, patients with type 1 CNV or patients with PED were more likely to remain stable. At present, the COVID-19 pandemic is becoming increasingly normalized, and the T&E regimen can become a more advanced treatment option for patients undergoing therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Retinal Detachment / Choroidal Neovascularization / Wet Macular Degeneration / COVID-19 / Macular Degeneration Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Adv Ther Journal subject: Therapeutics Year: 2022 Document Type: Article Affiliation country: S12325-021-01993-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Retinal Detachment / Choroidal Neovascularization / Wet Macular Degeneration / COVID-19 / Macular Degeneration Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Adv Ther Journal subject: Therapeutics Year: 2022 Document Type: Article Affiliation country: S12325-021-01993-3