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Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model.
Cochin, Maxime; Touret, Franck; Driouich, Jean-Sélim; Moureau, Gregory; Petit, Paul-Rémi; Laprie, Caroline; Solas, Caroline; de Lamballerie, Xavier; Nougairède, Antoine.
  • Cochin M; Unité des Virus Émergents, UVE: Aix Marseille Université, IRD 190, INSERM 1207, Marseille, France. Electronic address: maxime.cochin@univ-amu.fr.
  • Touret F; Unité des Virus Émergents, UVE: Aix Marseille Université, IRD 190, INSERM 1207, Marseille, France.
  • Driouich JS; Unité des Virus Émergents, UVE: Aix Marseille Université, IRD 190, INSERM 1207, Marseille, France.
  • Moureau G; Unité des Virus Émergents, UVE: Aix Marseille Université, IRD 190, INSERM 1207, Marseille, France.
  • Petit PR; Unité des Virus Émergents, UVE: Aix Marseille Université, IRD 190, INSERM 1207, Marseille, France.
  • Laprie C; Laboratoire Vet-Histo, Marseille, France.
  • Solas C; Unité des Virus Émergents, UVE: Aix Marseille Université, IRD 190, INSERM 1207, Marseille, France; Laboratoire de Pharmacocinétique et Toxicologie, Hôpital La Timone, APHM, Marseille, France.
  • de Lamballerie X; Unité des Virus Émergents, UVE: Aix Marseille Université, IRD 190, INSERM 1207, Marseille, France.
  • Nougairède A; Unité des Virus Émergents, UVE: Aix Marseille Université, IRD 190, INSERM 1207, Marseille, France. Electronic address: antoine.nougairede@univ-amu.fr.
Antiviral Res ; 197: 105212, 2022 01.
Article in English | MEDLINE | ID: covidwho-1530602
ABSTRACT
Drug repositioning has been used extensively since the beginning of the COVID-19 pandemic in an attempt to identify antiviral molecules for use in human therapeutics. Hydroxychloroquine and azithromycin have shown inhibitory activity against SARS-CoV-2 replication in different cell lines. Based on such in vitro data and despite the weakness of preclinical assessment, many clinical trials were set up using these molecules. In the present study, we show that hydroxychloroquine and azithromycin alone or combined does not block SARS-CoV-2 replication in human bronchial airway epithelia. When tested in a Syrian hamster model, hydroxychloroquine and azithromycin administrated alone or combined displayed no significant effect on viral replication, clinical course of the disease and lung impairments, even at high doses. Hydroxychloroquine quantification in lung tissues confirmed strong exposure to the drug, above in vitro inhibitory concentrations. Overall, this study does not support the use of hydroxychloroquine and azithromycin as antiviral drugs for the treatment of SARS-CoV-2 infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Azithromycin / SARS-CoV-2 / COVID-19 Drug Treatment / Hydroxychloroquine / Anti-Infective Agents Type of study: Experimental Studies / Prognostic study Limits: Animals / Female / Humans / Middle aged Language: English Journal: Antiviral Res Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Azithromycin / SARS-CoV-2 / COVID-19 Drug Treatment / Hydroxychloroquine / Anti-Infective Agents Type of study: Experimental Studies / Prognostic study Limits: Animals / Female / Humans / Middle aged Language: English Journal: Antiviral Res Year: 2022 Document Type: Article