COVID-19-associated psychosis: A systematic review of case reports.
Gen Hosp Psychiatry
; 73: 84-100, 2021.
Article
in English
| MEDLINE | ID: covidwho-1531268
ABSTRACT
OBJECTIVES:
To describe the comorbidities, presentations, and outcomes of adults with incident psychosis and a history of COVID-19.METHODS:
We completed a descriptive systematic review of case reports according to PRISMA guidelines, including cases of adult patients with incident psychosis and antecedent or concurrent COVID-19. We extracted patient demographics, comorbidities, clinical course, and outcomes, and assessed cases for quality using a standardized tool.RESULTS:
Of 2396 articles, we included 40 reports from 17 countries, comprising 48 patients. The mean age of patients was 43.9 years and 29 (60%) were males. A total of 7 (15%) had a documented psychiatric history, 6 (13%) had a substance use history and 11 (23%) had a comorbid medical condition. Delusions were the most common (44 [92%]) psychiatric sign and psychosis lasted between 2 and 90 days. A total of 33 (69%) patients required hospitalization to a medical service and 16 (33%) required inpatient psychiatric admission. The majority (26 [54%]) of cases did not assess for delirium and 15 (31%) cases were judged to be of high risk of bias.CONCLUSIONS:
Despite the growing awareness of COVID-19's association with incident psychosis at a population level, cases of COVID-19-associated psychosis often lacked clinically relevant details and delirium was frequently not excluded. PROSPERO registration number CRD42021256746.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Psychotic Disorders
/
COVID-19
Type of study:
Case report
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Gen Hosp Psychiatry
Year:
2021
Document Type:
Article
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