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COVID-19 vaccine safety and efficacy in patients with immune-mediated inflammatory disease: Review of available evidence.
Wack, Sarah; Patton, Timothy; Ferris, Laura K.
  • Wack S; Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Patton T; Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  • Ferris LK; Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address: ferrislk@upmc.edu.
J Am Acad Dermatol ; 85(5): 1274-1284, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1531500
ABSTRACT
Dermatologists diagnose and treat many immune-mediated inflammatory diseases (IMID). Understanding the inherent immune dysregulation of these diseases as well as the additional disruption that comes as a result of IMID treatments has been important during the COVID-19 pandemic. With vaccines becoming widely available, dermatologists need to be familiar with the risks and benefits of vaccination in these patients, particularly those taking biologics, in order to have informed discussions with their patients. In this review, we present the current evidence related to COVID-19 vaccine safety and efficacy in patients with IMID and review existing recommendations for vaccination against SARS-CoV-2. Given the current evidence, there is minimal concern that these patients are at any greater risk of harm from COVID-19 vaccination compared to healthy controls. For most, the benefit of avoiding severe COVID-19 through vaccination will outweigh the theoretical risk of these vaccines. A question that is still outstanding is whether patients on biologics will generate a sufficient immune response to the vaccine, which may be dependent on the specific biologic therapy and indication being treated. This underscores the importance of following patients with IMID after vaccination to determine the safety, efficacy, and duration of the vaccine in this population.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Immunocompromised Host / Dermatitis / COVID-19 Vaccines / COVID-19 Subject: Immunocompromised Host / Dermatitis / COVID-19 Vaccines / COVID-19 Type of study: Reviews / Evidence synthesis Language: English Journal: J Am Acad Dermatol Clinical aspect: Etiology / Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Immunocompromised Host / Dermatitis / COVID-19 Vaccines / COVID-19 Subject: Immunocompromised Host / Dermatitis / COVID-19 Vaccines / COVID-19 Type of study: Reviews / Evidence synthesis Language: English Journal: J Am Acad Dermatol Clinical aspect: Etiology / Therapy Year: 2021
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