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Usefulness of lung ultrasound for selecting asymptomatic older patients with COVID 19 pneumonia.
Okoye, Chukwuma; Calsolaro, Valeria; Fabbri, Alessandra; Franchi, Riccardo; Antognoli, Rachele; Zisca, Ludovica; Bianchi, Camilla; Calabrese, Alessia Maria; Rogani, Sara; Monzani, Fabio.
  • Okoye C; Geriatrics Unit, Department of Clinical & Experimental Medicine, University Hospital of Pisa, Via Paradisa, 2, 56124, Pisa, Italy.
  • Calsolaro V; Low Care Unit, Presidio Sanitario "Anna Torrigiani", Firenze, Italy.
  • Fabbri A; Geriatrics Unit, Department of Clinical & Experimental Medicine, University Hospital of Pisa, Via Paradisa, 2, 56124, Pisa, Italy.
  • Franchi R; Geriatrics Unit, Department of Clinical & Experimental Medicine, University Hospital of Pisa, Via Paradisa, 2, 56124, Pisa, Italy.
  • Antognoli R; Geriatrics Unit, Department of Clinical & Experimental Medicine, University Hospital of Pisa, Via Paradisa, 2, 56124, Pisa, Italy.
  • Zisca L; Geriatrics Unit, Department of Clinical & Experimental Medicine, University Hospital of Pisa, Via Paradisa, 2, 56124, Pisa, Italy.
  • Bianchi C; Low Care Unit, Presidio Sanitario "Anna Torrigiani", Firenze, Italy.
  • Calabrese AM; Low Care Unit, Presidio Sanitario "Anna Torrigiani", Firenze, Italy.
  • Rogani S; Geriatrics Unit, Department of Clinical & Experimental Medicine, University Hospital of Pisa, Via Paradisa, 2, 56124, Pisa, Italy.
  • Monzani F; Geriatrics Unit, Department of Clinical & Experimental Medicine, University Hospital of Pisa, Via Paradisa, 2, 56124, Pisa, Italy.
Sci Rep ; 11(1): 22892, 2021 11 24.
Article in English | MEDLINE | ID: covidwho-1532105
ABSTRACT
Clinical and prognostic differences between symptomatic and asymptomatic older patients with COVID-19 are of great interest since frail patients often show atypical presentation of illness. Lung Ultrasound (LUS) has been proven to be a reliable tool for detecting early-phase COVID-19 pneumonic alterations. The current prospective bicentric study aimed to compare LUS score and 3-month overall mortality between asymptomatic and symptomatic older patients with COVID-19, according to frailty status. Patients were stratified according to LUS score tertiles and Clinical Frailty Scale categories. Survival rate was assessed by telephone interviews 3 months after discharge. 64 symptomatic (24 women, aged 80.0 ± 10.8 years) and 46 asymptomatic (31 women, aged 84.3 ± 8.8 years) were consecutively enrolled. LUS score resulted an independent predictor of 3-month mortality [OR 2.27 (CI95% 1.09-4.8), p = 0.03], and the highest mortality rate was observed in symptomatic and asymptomatic pre-frail and frail patients (70.6% and 66.7%, respectively) with greater LUS abnormalities (3rd tertile). In conclusion, LUS identified an acute interstitial lung involvement in most of the older asymptomatic patients. Mortality rate progressively increased according to clinical frailty and LUS score degree, resulting a reliable prognostic tool in both symptomatic and asymptomatic patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-02275-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-02275-2