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Current and future strategies for diagnostic and management of obstructive sleep apnea.
Khurana, Sartaj; Soda, Narshone; Shiddiky, Muhammad J A; Nayak, Ranu; Bose, Sudeep.
  • Khurana S; Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India.
  • Soda N; Amity Institute of Molecular Medicine and Stem Cell Research, Amity University Uttar Pradesh, Noida, India.
  • Shiddiky MJA; Queensland Micro- and Nanotechnology Centre (Qmnc) and School of Environment and Science (ESC), Griffith University, Brisbane, Australia.
  • Nayak R; Queensland Micro- and Nanotechnology Centre (Qmnc) and School of Environment and Science (ESC), Griffith University, Brisbane, Australia.
  • Bose S; Amity Institute of Nanotechnology, Amity University Uttar Pradesh, Noida, India.
Expert Rev Mol Diagn ; 21(12): 1287-1301, 2021 12.
Article in English | MEDLINE | ID: covidwho-1532339
ABSTRACT

INTRODUCTION:

Obstructive sleep apnea (OSA) is a common sleep disorder with multiple comorbidities including hypertension, diabetes, and cardiovascular disorders. Detected based on an overnight sleep study is called polysomnography (PSG); OSA still remains undiagnosed in majority of the population mainly attributed to lack of awareness. To overcome the limitations posed by PSG such as patient discomfort and overnight hospitalization, newer technologies are being explored. In addition, challenges associated with current management of OSA using continuous positive airway pressure (CPAP), etc. presents several pitfalls. AREAS COVERED Conventional and modern detection/management techniques including PSG, CPAP, smart wearable/pillows, bio-motion sensors, etc., have both pros and cons. To fulfill the limitations in OSA diagnostics, there is an imperative need for new technology for screening of symptomatic and more importantly asymptomatic OSA patients to reduce the risk of several associated life-threatening comorbidities. In this line, molecular marker-based diagnostics have shown great promises. EXPERT OPINION A detailed overview is presented on the OSA management and diagnostic approaches and recent advances in the molecular screening methods. The potentials of biomarker-based detection and its limitations are also portrayed and a comparison between the standard, current modern approaches, and promising futuristic technologies for OSA diagnostics and management is set forth.ABBREVIATIONS AHI Apnea hypopnea index; AI artificial intelligence; CAM Cell adhesion molecules; CPAP Continuous Positive Airway Pressure; COVID-19 Coronavirus Disease 2019; CVD Cardiovascular disease; ELISA Enzyme linked immunosorbent assay; HSAT Home sleep apnea testing; IR-UWB Impulse radio-ultra wideband; MMA maxillomandibular advancement; PSG Polysomnography; OSA Obstructive sleep apnea; SOD Superoxide dismutase; QD Quantum dot.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sleep Apnea, Obstructive Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: 14737159.2021.2002686

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sleep Apnea, Obstructive Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: 14737159.2021.2002686