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Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response.
Murugesan, Kanagavel; Jagannathan, Prasanna; Pham, Tho D; Pandey, Suchitra; Bonilla, Hector F; Jacobson, Karen; Parsonnet, Julie; Andrews, Jason R; Weiskopf, Daniela; Sette, Alessandro; Pinsky, Benjamin A; Singh, Upinder; Banaei, Niaz.
  • Murugesan K; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Jagannathan P; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Pham TD; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Pandey S; Stanford Blood Center, Stanford Health Care, Stanford, California, USA.
  • Bonilla HF; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
  • Jacobson K; Stanford Blood Center, Stanford Health Care, Stanford, California, USA.
  • Parsonnet J; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Andrews JR; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Weiskopf D; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Sette A; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Pinsky BA; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
  • Singh U; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
  • Banaei N; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, California, USA.
Clin Infect Dis ; 73(9): e3130-e3132, 2021 11 02.
Article in English | MEDLINE | ID: covidwho-1532491
ABSTRACT
We investigated feasibility and accuracy of an interferon-γ release assay (IGRA) for detection of T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whole blood IGRA accurately distinguished between convalescent and uninfected healthy blood donors with a predominantly CD4+ T-cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the coronavirus disease 2019 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon-gamma Release Tests / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon-gamma Release Tests / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid