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Model-informed COVID-19 vaccine prioritization strategies by age and serostatus.
Bubar, Kate M; Reinholt, Kyle; Kissler, Stephen M; Lipsitch, Marc; Cobey, Sarah; Grad, Yonatan H; Larremore, Daniel B.
  • Bubar KM; Department of Applied Mathematics, University of Colorado Boulder, Boulder, CO 80309, USA. kate.bubar@colorado.edu daniel.larremore@colorado.edu.
  • Reinholt K; IQ Biology Program, University of Colorado Boulder, Boulder, CO 80303, USA.
  • Kissler SM; Department of Computer Science, University of Colorado Boulder, Boulder, CO 80309, USA.
  • Lipsitch M; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
  • Cobey S; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
  • Grad YH; Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
  • Larremore DB; Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA.
Science ; 371(6532): 916-921, 2021 02 26.
Article in English | MEDLINE | ID: covidwho-1532943
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Semantic information from SemMedBD (by NLM)
1. IMPACT gene AFFECTS COVID-19
Subject
IMPACT gene
Predicate
AFFECTS
Object
COVID-19
2. IMPACT gene AFFECTS COVID-19
Subject
IMPACT gene
Predicate
AFFECTS
Object
COVID-19
ABSTRACT
Limited initial supply of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine raises the question of how to prioritize available doses. We used a mathematical model to compare five age-stratified prioritization strategies. A highly effective transmission-blocking vaccine prioritized to adults ages 20 to 49 years minimized cumulative incidence, but mortality and years of life lost were minimized in most scenarios when the vaccine was prioritized to adults greater than 60 years old. Use of individual-level serological tests to redirect doses to seronegative individuals improved the marginal impact of each dose while potentially reducing existing inequities in COVID-19 impact. Although maximum impact prioritization strategies were broadly consistent across countries, transmission rates, vaccination rollout speeds, and estimates of naturally acquired immunity, this framework can be used to compare impacts of prioritization strategies across contexts.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Mass Vaccination / COVID-19 Vaccines / COVID-19 / Health Priorities Subject: Mass Vaccination / COVID-19 Vaccines / COVID-19 / Health Priorities Type of study: Prognostic study Language: English Journal: Science Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Mass Vaccination / COVID-19 Vaccines / COVID-19 / Health Priorities Subject: Mass Vaccination / COVID-19 Vaccines / COVID-19 / Health Priorities Type of study: Prognostic study Language: English Journal: Science Year: 2021
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