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Sleep Disruption and Depression, Stress and Anxiety Levels in Women With Polycystic Ovary Syndrome (PCOS) During the Lockdown Measures for COVID-19 in the UK.
Kite, Chris; Atkinson, Lou; McGregor, Gordon; Clark, Cain C T; Brown, James E; Kyrou, Ioannis; Randeva, Harpal S.
  • Kite C; Centre for Active Living, University of Chester, University Centre Shrewsbury, Shrewsbury, United Kingdom.
  • Atkinson L; School of Biosciences, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.
  • McGregor G; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry & Warwickshire National Health Service (NHS) Trust, Coventry, United Kingdom.
  • Clark CCT; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry & Warwickshire National Health Service (NHS) Trust, Coventry, United Kingdom.
  • Brown JE; School of Psychology, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.
  • Kyrou I; Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire National Health Service (NHS) Trust, Coventry, United Kingdom.
  • Randeva HS; Centre for Sport Exercise & Life Sciences, Coventry University, Coventry, United Kingdom.
Front Glob Womens Health ; 2: 649104, 2021.
Article in English | MEDLINE | ID: covidwho-1533667
ABSTRACT

Background:

Lockdown measures have been enforced globally in response to the COVID-19 pandemic. Given the comorbidity burden in women with polycystic ovary syndrome (PCOS), these lockdown measures may have a particularly negative impact on sleep health, quality of life (QoL), and depression/stress levels in this population. The aim of this study was to explore whether such potential problems were present in women with PCOS during the COVID-19 lockdown in the UK.

Methods:

UK women with PCOS were recruited through social media into a cross-sectional study during the COVID-19 lockdown. The study survey was delivered online, and included demographic and COVID-19 relevant questions, as well as validated questionnaires/scales, namely the Insomnia Severity Index (ISI), Depression Anxiety and Stress Scale (DASS-21), and PCOSQOL questionnaire.

Results:

Three hundred and thirty-three women with PCOS [median age 30.0 (9.0) years] were recruited. Participants were dichotomized based on responses regarding the impact of COVID-19 restrictions on their sleep [negative (N = 242) vs. no/positive (N = 91) impact]. No differences were noted between groups regarding age, time since PCOS diagnosis, body mass index, or number of comorbidities. Based on the ISI, 44.2% of participants reporting a negative impact on sleep exhibited at least moderately severe clinical insomnia. Compared to those who reported no/positive effect on sleep, the participants reporting a negative impact on sleep also reported poorer QoL, based on the total PCOSQOL score, with a greater impact of PCOS and poorer mood in the corresponding PCOSQOL domains. Based on the DASS-21, the latter also had statistically higher depression and stress levels compared to the former. Finally, for this cohort significant inverse correlations were noted between the ISI and PCOSQOL scores (total and domain scores), whilst the DASS-21 and ISI scores were positively correlated (all p-values <0.001).

Conclusion:

The majority of recruited UK women with PCOS reported that the COVID-19 lockdown had a negative impact on their sleep, which was also associated with impaired QoL and higher depression/stress levels. Whilst further research is required, women with PCOS should be considered a vulnerable population that may experience an adverse impact on sleep, QoL and mental health well-being due to lockdown measures during the COVID-19 pandemic.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Front Glob Womens Health Year: 2021 Document Type: Article Affiliation country: Fgwh.2021.649104

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Front Glob Womens Health Year: 2021 Document Type: Article Affiliation country: Fgwh.2021.649104