Your browser doesn't support javascript.
Regenerating Damaged Myocardium: A Review of Stem-Cell Therapies for Heart Failure.
Fan, Dihan; Wu, Hanrong; Pan, Kaichao; Peng, Huashan; Wu, Rongxue.
  • Fan D; Psychiatric Genetics Group, McGill University, Montreal, QC H4H 1R3, Canada.
  • Wu H; Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada.
  • Pan K; Psychiatric Genetics Group, McGill University, Montreal, QC H4H 1R3, Canada.
  • Peng H; Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada.
  • Wu R; Division of Cardiology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Cells ; 10(11)2021 11 11.
Article in English | MEDLINE | ID: covidwho-1533815
ABSTRACT
Cardiovascular disease (CVD) is one of the contributing factors to more than one-third of human mortality and the leading cause of death worldwide. The death of cardiac myocyte is a fundamental pathological process in cardiac pathologies caused by various heart diseases, including myocardial infarction. Thus, strategies for replacing fibrotic tissue in the infarcted region with functional myocardium have long been a goal of cardiovascular research. This review begins by briefly discussing a variety of somatic stem- and progenitor-cell populations that were frequently studied in early investigations of regenerative myocardial therapy and then focuses primarily on pluripotent stem cells (PSCs), especially induced-pluripotent stem cells (iPSCs), which have emerged as perhaps the most promising source of cardiomyocytes for both therapeutic applications and drug testing. We also describe attempts to generate cardiomyocytes directly from cardiac fibroblasts (i.e., transdifferentiation), which, if successful, may enable the pool of endogenous cardiac fibroblasts to be used as an in-situ source of cardiomyocytes for myocardial repair.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Regeneration / Stem Cell Transplantation / Heart Failure / Myocardium Type of study: Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10113125

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Regeneration / Stem Cell Transplantation / Heart Failure / Myocardium Type of study: Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10113125