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Therapeutic Deep Eutectic Systems towards the Treatment of Tuberculosis and Colorectal Cancer: Opportunities and Challenges.
Oliveira, Filipe; Santos, Filipa; Duarte, Ana Rita C.
  • Oliveira F; Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Chemistry Department, NOVA School of Science and Technology, 2829-516 Caparica, Portugal.
  • Santos F; Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Chemistry Department, NOVA School of Science and Technology, 2829-516 Caparica, Portugal.
  • Duarte ARC; Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Chemistry Department, NOVA School of Science and Technology, 2829-516 Caparica, Portugal.
Molecules ; 26(22)2021 Nov 20.
Article in English | MEDLINE | ID: covidwho-1534201
ABSTRACT
What if a new technology based on therapeutic deep eutectic systems would disrupt the current treatment of major economic and socially burden diseases? The classical definition of eutectic systems is that they are the combination of two or more compounds that interact via hydrogen bonds, from which results a melting temperature depression in comparison with that of its individual components. Therapeutic deep eutectic systems are defined as eutectic systems in which at least one of the individual components is an active pharmaceutical ingredient, or a eutectic system in which the active pharmaceutical ingredient is dissolved. Current literature reports on tuberculosis have been mostly based on the most common anti-tuberculosis drugs prescribed. Using eutectic systems based on naturally occurring molecules known for their anti-microbial activity may also present a promising therapeutic strategy able to cope with the prevalence of Mycobacterium tuberculosis and prevent the appearance of multidrug resistance strains. With regards to colorectal cancer, literature has been unravelling combinations of terpenes with anti-inflammatory drugs that are selectively cytotoxic towards colorectal cancer cells and do not compromise the viability of normal intestinal cells. This technology could contribute to preventing tumor growth and metastasis while providing a patient compliance therapeutics, which will be crucial to the success of overcoming the challenges presented by cancers.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / Colorectal Neoplasms / Drug Delivery Systems / Mycobacterium tuberculosis / Antineoplastic Agents / Antitubercular Agents Type of study: Observational study Limits: Humans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26227022

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / Colorectal Neoplasms / Drug Delivery Systems / Mycobacterium tuberculosis / Antineoplastic Agents / Antitubercular Agents Type of study: Observational study Limits: Humans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26227022