Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis.
Pharmaceuticals (Basel)
; 14(11)2021 Nov 04.
Article
in English
| MEDLINE | ID: covidwho-1534223
ABSTRACT
Viral infections cause many severe human diseases, being responsible for remarkably high mortality rates. In this sense, both the academy and the pharmaceutical industry are continuously searching for new compounds with antiviral activity, and in addition, face the challenge of developing greener and more efficient methods to synthesize these compounds. This becomes even more important with drugs possessing stereogenic centers as highly enantioselective processes are required. In this minireview, the advances achieved to improve synthetic routes efficiency and sustainability of important commercially antiviral chiral drugs are discussed, highlighting the use of organocatalytic methods.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Ph14111125
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