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CRISPR Screening: Molecular Tools for Studying Virus-Host Interactions.
Chulanov, Vladimir; Kostyusheva, Anastasiya; Brezgin, Sergey; Ponomareva, Natalia; Gegechkori, Vladimir; Volchkova, Elena; Pimenov, Nikolay; Kostyushev, Dmitry.
  • Chulanov V; National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia.
  • Kostyusheva A; Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia.
  • Brezgin S; Department of Infectious Diseases, Sechenov University, 119991 Moscow, Russia.
  • Ponomareva N; National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia.
  • Gegechkori V; National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia.
  • Volchkova E; Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia.
  • Pimenov N; National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia.
  • Kostyushev D; Department of Pharmaceutical and Toxicological Chemistry, Sechenov University, 119991 Moscow, Russia.
Viruses ; 13(11)2021 11 11.
Article in English | MEDLINE | ID: covidwho-1534242
ABSTRACT
CRISPR/Cas is a powerful tool for studying the role of genes in viral infections. The invention of CRISPR screening technologies has made it possible to untangle complex interactions between the host and viral agents. Moreover, whole-genome and pathway-specific CRISPR screens have facilitated identification of novel drug candidates for treating viral infections. In this review, we highlight recent developments in the fields of CRISPR/Cas with a focus on the use of CRISPR screens for studying viral infections and identifying new candidate genes to aid development of antivirals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / Virus Diseases / Genetic Techniques / Genome-Wide Association Study / High-Throughput Screening Assays / CRISPR-Cas Systems Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13112258

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viruses / Virus Diseases / Genetic Techniques / Genome-Wide Association Study / High-Throughput Screening Assays / CRISPR-Cas Systems Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: V13112258