Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
Respir Med
; 168: 105996, 2020 07.
Article
in English
| MEDLINE | ID: covidwho-153451
ABSTRACT
SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global health issue. Mechanisms implicated in virus/host cells interaction are central for cell infection and replication that in turn lead to disease onset and local damage. To enter airway and lung epithelia, SARS-CoV-2 attaches to ACE2 receptors by spike (S) glycoproteins. Molecular mechanisms that promote interaction between SARS-CoV-2 virus and host with particular focus on virus cell entry receptor ACE2 are described. We further explore the impact of underlying medical conditions and therapies including renin-angiotensin inhibitors on modulating ACE 2, which is the major SARS-CoV-2 cell entry receptor.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Receptors, Virus
/
Angiotensin-Converting Enzyme Inhibitors
/
Coronavirus Infections
/
Peptidyl-Dipeptidase A
/
Virus Internalization
/
Angiotensin Receptor Antagonists
/
Betacoronavirus
Limits:
Humans
Language:
English
Journal:
Respir Med
Year:
2020
Document Type:
Article
Affiliation country:
J.rmed.2020.105996
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