Forensic autopsy-confirmed COVID-19-induced out-of-hospital cardiac arrest.
Ann Transl Med
; 9(23): 1715, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1535003
ABSTRACT
BACKGROUND:
In the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, data from autopsy in subjects who died at home during lockdown are scarce. We here report the first forensic autopsy series of coronavirus disease 2019 (COVID-19)-related out-of-hospital cardiac arrest (OHCA).METHODS:
Between March and April 2020, four COVID-19-related OHCA were autopsied at the Institute of Legal Medicine of the metropolitan area of Lyon (France) according safe recommended procedures.RESULTS:
Four Caucasian individuals (3 men/1 woman; age 56.8±2.1 years, body mass index 29.5±7.4 kg/m2), presenting symptomatic COVID-19 were autopsied. Autopsies of 3 individuals reported natural death by acute respiratory failure implicating SARS-CoV-2 with typical COVID-19 pulmonary aspect of gross findings and pulmonary microscopy findings, i.e., diffusely congestive edematous lungs with peripheral thrombi and diffuse alveolar damage (DAD) at different stages of inflammatory reaction. For one individual, autopsy concluded of violent death due to suicidal acute alcohol intoxication in a patient that could no longer endure COVID-19 lockdown. No significant lesions were found in the heart.CONCLUSIONS:
We report here OHCAs of non-cardiac cause directly implicating COVID-19 at various stages of SARS-CoV-2-related DAD. Thus, autopsy remain of interest during this epidemic, both legally and medically to better understand the pathogenic processes of this emerging infectious disease.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Topics:
Long Covid
Language:
English
Journal:
Ann Transl Med
Year:
2021
Document Type:
Article
Affiliation country:
Atm-21-3918
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