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The innate immune system in human kidney inflammaging.
Sepe, Vincenzo; Libetta, Carmelo; Gregorini, Marilena; Rampino, Teresa.
  • Sepe V; Unit of Nephrology, Dialysis, Transplantation, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy. v.sepe@smatteo.pv.it.
  • Libetta C; Unit of Nephrology, Dialysis, Transplantation, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy.
  • Gregorini M; Department of Internal Medicine and Therapeutics, University of Pavia, Via Aselli, 43/45, 27100, Pavia, Italy.
  • Rampino T; Unit of Nephrology, Dialysis, Transplantation, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy.
J Nephrol ; 35(2): 381-395, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1536386
ABSTRACT
Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis and aging. The innate immune system is characterized by a limited number of receptors, constantly challenged by self and non-self stimuli. Circulating and kidney resident myeloid and lymphoid cells are all equipped with pattern recognition receptors (PRRs). Recent reports on PRRs show kidney overexpression of toll-like receptors (TLRs) in inflammaging autoimmune renal diseases, vasculitis, acute kidney injury and kidney transplant rejection. TLR upregulation leads to proinflammatory cytokine induction, fibrosis, and chronic kidney disease progression. TLR2 blockade in a murine model of renal ischemia reperfusion injury prevented the escape of natural killer cells and neutrophils by inflammaging kidney injury. Tumor necrosis factor-α blockade in endothelial cells with senescence-associated secretory phenotype significantly reduced interleukin-6 release. These findings should encourage experimental and translational clinical trials aimed at modulating renal inflammaging by native immunity blockade.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelial Cells / Acute Kidney Injury Type of study: Prognostic study Limits: Aged / Animals / Humans Language: English Journal: J Nephrol Journal subject: Nephrology Year: 2022 Document Type: Article Affiliation country: S40620-021-01153-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelial Cells / Acute Kidney Injury Type of study: Prognostic study Limits: Aged / Animals / Humans Language: English Journal: J Nephrol Journal subject: Nephrology Year: 2022 Document Type: Article Affiliation country: S40620-021-01153-4