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Predictive scores for the diagnosis of Pulmonary Embolism in COVID-19: A systematic review.
Rindi, Lorenzo Vittorio; Al Moghazi, Samir; Donno, Davide Roberto; Cataldo, Maria Adriana; Petrosillo, Nicola.
  • Rindi LV; Department of Systems Medicine, Infectious Disease Clinic, Tor Vergata University, Via Montpellier, 1 - 00133 Rome, Italy.
  • Al Moghazi S; Clinical and Research Department on Infectious Diseases, National Institute for Infectious Diseases "L. Spallanzani", Via Portuense, 292 - 00147 Rome, Italy.
  • Donno DR; Clinical and Research Department on Infectious Diseases, National Institute for Infectious Diseases "L. Spallanzani", Via Portuense, 292 - 00147 Rome, Italy.
  • Cataldo MA; Epidemiology and Pre-clinical Research Department, National Institute for Infectious Diseases "L. Spallanzani", Via Portuense, 292 - 00147 Rome, Italy. Electronic address: adriana.cataldo@inmi.it.
  • Petrosillo N; Clinical and Research Department on Infectious Diseases, National Institute for Infectious Diseases "L. Spallanzani", Via Portuense, 292 - 00147 Rome, Italy.
Int J Infect Dis ; 115: 93-100, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1536605
ABSTRACT

OBJECTIVES:

During the COVID-19 pandemic, several studies described an increased chance of developing pulmonary embolism (PE). Several scores have been used to predict the occurrence of PE. This systematic review summarizes the literature on predicting rules for PE in hospitalized COVID-19 patients (HCPs).

METHODS:

PUBMED and EMBASE databases were searched to identify articles (1 January 2020-28 April 2021) presenting data pertaining to the use of a prediction rule to assess the risk for PE in adult HCPs. The investigated outcome was the diagnosis of PE. Studies presenting data using a single laboratory assay for PE prediction were excluded. Included studies were appraised for methodological quality using the Newcastle - Ottawa Quality Assessment Scale for Cohort Studies (NOS).

RESULTS:

We obtained a refined pool of twelve studies for five scoring systems (Wells score, Geneva score, CHADS2/CHA2DS2VASc/M-CHA2DS2VASc, CHOD score, Padua Prediction Score), and 4,526 patients. Only one score was designed explicitly for HCPs. Three and nine included studies were prospective and retrospective cohort studies, respectively. Among the examined scores, the CHOD score seems promising for predictive ability.

CONCLUSION:

New prediction rules, specifically developed and validated for estimating the risk of PE in HCP, differentiating ICU from non-ICU patients, and taking into account anticoagulation prophylaxis, comorbidities, and the time from COVID-19 diagnosis are needed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Adult / Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.11.038

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Adult / Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.11.038