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Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses.
Song, Woo-Jung; Hui, Christopher K M; Hull, James H; Birring, Surinder S; McGarvey, Lorcan; Mazzone, Stuart B; Chung, Kian Fan.
  • Song WJ; Department of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  • Hui CKM; Royal Free Hampstead NHS Foundation Trust, London, UK.
  • Hull JH; Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, UK.
  • Birring SS; Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
  • McGarvey L; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
  • Mazzone SB; Department of Anatomy and Physiology, University of Melbourne, VIC, Australia.
  • Chung KF; Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, UK; Experimental Studies Unit, National Heart & Lung Institute, Imperial College London, UK. Electronic address: f.chung@imperial.ac.uk.
Lancet Respir Med ; 9(5): 533-544, 2021 05.
Article in English | MEDLINE | ID: covidwho-1537202
Semantic information from SemMedBD (by NLM)
1. Dyspnea COEXISTS_WITH COVID-19
Subject
Dyspnea
Predicate
COEXISTS_WITH
Object
COVID-19
2. Pain COEXISTS_WITH COVID-19
Subject
Pain
Predicate
COEXISTS_WITH
Object
COVID-19
3. Impaired cognition COEXISTS_WITH COVID-19
Subject
Impaired cognition
Predicate
COEXISTS_WITH
Object
COVID-19
4. Chronic fatigue COEXISTS_WITH COVID-19
Subject
Chronic fatigue
Predicate
COEXISTS_WITH
Object
COVID-19
5. COVID-19 ASSOCIATED_WITH Biochemical Pathway
Subject
COVID-19
Predicate
ASSOCIATED_WITH
Object
Biochemical Pathway
6. Brain LOCATION_OF Syndrome
Subject
Brain
Predicate
LOCATION_OF
Object
Syndrome
7. Syndrome AFFECTS COVID-19
Subject
Syndrome
Predicate
AFFECTS
Object
COVID-19
8. Anti-Inflammatory Agents TREATS Coughing
Subject
Anti-Inflammatory Agents
Predicate
TREATS
Object
Coughing
9. Dyspnea COEXISTS_WITH COVID-19
Subject
Dyspnea
Predicate
COEXISTS_WITH
Object
COVID-19
10. Pain COEXISTS_WITH COVID-19
Subject
Pain
Predicate
COEXISTS_WITH
Object
COVID-19
11. Impaired cognition COEXISTS_WITH COVID-19
Subject
Impaired cognition
Predicate
COEXISTS_WITH
Object
COVID-19
12. Chronic fatigue COEXISTS_WITH COVID-19
Subject
Chronic fatigue
Predicate
COEXISTS_WITH
Object
COVID-19
13. COVID-19 ASSOCIATED_WITH Biochemical Pathway
Subject
COVID-19
Predicate
ASSOCIATED_WITH
Object
Biochemical Pathway
14. Brain LOCATION_OF Syndrome
Subject
Brain
Predicate
LOCATION_OF
Object
Syndrome
15. Syndrome AFFECTS COVID-19
Subject
Syndrome
Predicate
AFFECTS
Object
COVID-19
16. Anti-Inflammatory Agents TREATS Coughing
Subject
Anti-Inflammatory Agents
Predicate
TREATS
Object
Coughing
ABSTRACT
Cough is one of the most common presenting symptoms of COVID-19, along with fever and loss of taste and smell. Cough can persist for weeks or months after SARS-CoV-2 infection, often accompanied by chronic fatigue, cognitive impairment, dyspnoea, or pain-a collection of long-term effects referred to as the post-COVID syndrome or long COVID. We hypothesise that the pathways of neurotropism, neuroinflammation, and neuroimmunomodulation through the vagal sensory nerves, which are implicated in SARS-CoV-2 infection, lead to a cough hypersensitivity state. The post-COVID syndrome might also result from neuroinflammatory events in the brain. We highlight gaps in understanding of the mechanisms of acute and chronic COVID-19-associated cough and post-COVID syndrome, consider potential ways to reduce the effect of COVID-19 by controlling cough, and suggest future directions for research and clinical practice. Although neuromodulators such as gabapentin or opioids might be considered for acute and chronic COVID-19 cough, we discuss the possible mechanisms of COVID-19-associated cough and the promise of new anti-inflammatories or neuromodulators that might successfully target both the cough of COVID-19 and the post-COVID syndrome.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuroimmunomodulation / Cough / COVID-19 / Inflammation / Nervous System Diseases Type of study: Risk factors Topics: Long Covid Limits: Humans Language: English Journal: Lancet Respir Med Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuroimmunomodulation / Cough / COVID-19 / Inflammation / Nervous System Diseases Type of study: Risk factors Topics: Long Covid Limits: Humans Language: English Journal: Lancet Respir Med Year: 2021 Document Type: Article