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On-demand nanozyme signal enhancement at the push of a button for the improved detection of SARS-CoV-2 nucleocapsid protein in serum.
Bradbury, Daniel W; Trinh, Jasmine T; Ryan, Milo J; Cantu, Cassandra M; Lu, Jiakun; Nicklen, Frances D; Du, Yushen; Sun, Ren; Wu, Benjamin M; Kamei, Daniel T.
  • Bradbury DW; Department of Bioengineering, University of California, Los Angeles, CA 90095, USA. kamei@seas.ucla.edu.
  • Trinh JT; Department of Bioengineering, University of California, Los Angeles, CA 90095, USA. kamei@seas.ucla.edu.
  • Ryan MJ; Department of Bioengineering, University of California, Los Angeles, CA 90095, USA. kamei@seas.ucla.edu.
  • Cantu CM; Department of Bioengineering, University of California, Los Angeles, CA 90095, USA. kamei@seas.ucla.edu.
  • Lu J; Department of Bioengineering, University of California, Los Angeles, CA 90095, USA. kamei@seas.ucla.edu.
  • Nicklen FD; Department of Bioengineering, University of California, Los Angeles, CA 90095, USA. kamei@seas.ucla.edu.
  • Du Y; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
  • Sun R; ZJU-UCLA Joint Center for Medical Education and Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
  • Wu BM; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
  • Kamei DT; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Analyst ; 146(24): 7386-7393, 2021 Dec 06.
Article in English | MEDLINE | ID: covidwho-1537342
ABSTRACT
We developed an innovative 3D printed casing that incorporates a lateral-flow immunoassay, dehydrated signal enhancement reagents, and a sealed buffer chamber. With only the push of a button for signal enhancement, our device detected the SARS-CoV-2 N-protein in 40 min at concentrations as low as 0.1 ng mL-1 in undiluted serum.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: Analyst Year: 2021 Document Type: Article Affiliation country: D1an01350e

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: Analyst Year: 2021 Document Type: Article Affiliation country: D1an01350e