Human placental biology at single-cell resolution: a contemporaneous review.
BJOG
; 129(2): 208-220, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1537791
ABSTRACT
Single-cell technologies capture cellular heterogeneity to focus on previously poorly described subpopulations of cells. Work by our laboratory and many others has metagenomically characterised a low biomass intrauterine microbial community, alongside microbial transcripts, antigens and metabolites, but the functional importance of low biomass microbial communities in placental immuno-microenvironments is still being elucidated. Given their hypothesised role in modulating inflammation and immune ontogeny to enable tolerance of beneficial microbes while warding off pathogens, there is a need for single-cell resolution. Herein, we summarise the potential for mechanistic understanding of these and other key fundamental early developmental processes by applying single-cell approaches.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Placenta
/
Single-Cell Analysis
Type of study:
Diagnostic study
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
BJOG
Journal subject:
Gynecology
/
Obstetrics
Year:
2022
Document Type:
Article
Affiliation country:
1471-0528.16970
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