Chlorhexidine mouthwash reduces the salivary viral load of SARS-CoV-2: A randomized clinical trial.
Oral Dis
; 28 Suppl 2: 2500-2508, 2022 Nov.
Article
in English
| MEDLINE | ID: covidwho-1537848
ABSTRACT
OBJECTIVES:
This study aimed to evaluate the effect of 0.12% chlorhexidine gluconate on the salivary load of SARS-CoV-2. MATERIALS ANDMETHODS:
A randomized, double-blind, placebo-controlled trial was performed on 100 participants positive for SARS-CoV-2. In the test group (n = 50), volunteers gargled with a mouthwash containing 15 ml of 0.12% chlorhexidine gluconate for 1 min, while the control group (n = 50) used a placebo. Saliva samples were obtained before (baseline) and 5 and 60 min after using the solutions. Real-time reverse transcription polymerase chain reaction assays (qRT-PCR) were carried out and the cycle threshold (Ct) was computed. The chi-square test and t-test were used for group comparison (p ≤ 0.05).RESULTS:
The differences in Ct values between the 5-min evaluation and baseline (test group 2.19 ± 4.30; control -0.40 ± 3.87, p = 0.002) and between 60 min and baseline (test group 2.45 ± 3.88; control 0.76 ± 4.41, p = 0.05) were significantly greater in the test group, revealing a reduction of viral load. Furthermore, there was a reduction in the load of SARS-CoV-2 in 72% of the volunteers using chlorhexidine versus 30% in the control group (p = 0.001).CONCLUSIONS:
Chlorhexidine gluconate (0.12%) was effective in reducing salivary SARS-CoV-2 load for at least 60 min.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Oral Dis
Journal subject:
Dentistry
Year:
2022
Document Type:
Article
Affiliation country:
Odi.14086
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