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Association of Metabolic Syndrome with COVID-19 in the Republic of Korea.
Jeon, Woo-Hwi; Seon, Jeong-Yeon; Park, So-Youn; Oh, In-Hwan.
  • Jeon WH; Department of Preventive Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
  • Seon JY; Department of Preventive Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
  • Park SY; Department of Medical Education and Humanities, College of Medicine, Kyung Hee University, Seoul, Korea.
  • Oh IH; Department of Preventive Medicine, College of Medicine, Kyung Hee University, Seoul, Korea.
Diabetes Metab J ; 46(3): 427-438, 2022 05.
Article in English | MEDLINE | ID: covidwho-1538636
ABSTRACT

BACKGROUND:

Metabolic syndrome (MetS) is reportedly a crucial risk factor for coronavirus disease 2019 (COVID-19). Since the epidemiological studies that examine this association are few and include small samples, we investigated the relationship between MetS and COVID-19 severity and death using a larger sample in the Republic of Korea.

METHODS:

We analyzed 66,321 patients, 4,066 of whom had COVID-19. We used chi-square tests to examine patients' characteristics. We performed logistic regression analysis to analyze differences in COVID-19 infection and clinical outcomes according to the presence of MetS.

RESULTS:

Although MetS was not significantly associated with COVID-19 risk, acquiring MetS was significantly associated with the risk of severe COVID-19 outcomes (odds ratio [OR], 1.97; 95% confidence interval [CI], 1.34 to 2.91; P=0.001). The mortality risk was significantly higher in COVID-19 patients with MetS (OR, 1.74; 95% CI, 1.17 to 2.59; P=0.006). Patients with abnormal waist circumference were approximately 2.07 times more likely to develop severe COVID-19 (P<0.001), and high-density lipoprotein cholesterol (HDL-C) levels were significantly associated with COVID-19; the mortality risk due to COVID-19 was 1.74 times higher in men with an HDL-C level of <40 mg/dL and in women with an HDL-C level of <50 mg/dL (P=0.012).

CONCLUSION:

COVID-19 is likely associated with severity and death in patients with MetS or in patients with MetS risk factors. Therefore, patients with MetS or those with abnormal waist circumference and HDL-C levels need to be treated with caution.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Metabolic Syndrome / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Diabetes Metab J Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Metabolic Syndrome / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Diabetes Metab J Year: 2022 Document Type: Article